中华眼科医学杂志(电子版)
中華眼科醫學雜誌(電子版)
중화안과의학잡지(전자판)
CHINESE JOURNAL OF OPHTHALMOLOGIC MEDICINE(ELECTRONIC EDITION)
2013年
1期
14-17
,共4页
颈内动脉狭窄%眼部缺血性表现%临床特征%治疗效果
頸內動脈狹窄%眼部缺血性錶現%臨床特徵%治療效果
경내동맥협착%안부결혈성표현%림상특정%치료효과
Carotid artery stenosis%Ocular ischemia%Clinical features%Therapeutic effect
目的:探讨颈内动脉狭窄伴眼部缺血性表现患者的临床特征和治疗效果。方法回顾性分析齐齐哈尔医学院第五临床医学院眼科2011年12月至2012年12月期间71例(71只眼)颈内动脉狭窄伴眼部缺血性表现患者的临床资料,描述患者颈内动脉狭窄伴眼部缺血性情况。因为对疗效数据为有序数据,故采用Kruskal-Wallis H秩和检验的方法进行比较。以P<0.05为差异有统计学意义。当差异有统计学意义时,对3组之间的疗效进行两两比较。结果71例患者中,一过性黑矇者33例(33只眼),眼前闪光者25例(25只眼),眼部红肿伴有眼眶周围疼痛者23例(23只眼),复视者7例(7只眼),视力下降者4例(4只眼)。27例眼部缺血性疾病确诊患者中,缺血性视神经病变者8例(8只眼),眼部缺血综合征者55例(55只眼),视网膜中央分支动脉阻塞者6例(6只眼),视网膜出血者4例(4只眼),眼外肌麻痹者3例(3只眼),新生血管性青光眼1例(1只眼),颈内动脉狭窄程度和眼部缺血性疾病的发生率呈高度正相关。单纯药物治疗后显效者2只眼(13.3%),有效者4只眼(26.7%),无效者9只眼(60.0%),总有效率40.0%;颈内动脉内膜切除术后显效者10只眼(43.5%),有效者11只眼(47.8%),无效者2只眼(8.7%),总有效率91.3%;颈内动脉支架置入术后显效者11只眼(47.8%),有效者8只眼(34.8%),无效者4只眼(17.4%),总有效率82.6%,采取颈内动脉支架置入术和颈内动脉内膜切除术的治疗效果明显优于单纯药物治疗,差异有统计学意义(Hc=9.60,7.68;P=0.002,0.006)。结论颈内动脉狭窄伴眼部缺血性表现的患者,临床特征较为多样,可出现多种眼部缺血性疾病,行颈内动脉支架置入术或颈内动脉内膜切除术,可获得较好的临床治疗效果。
目的:探討頸內動脈狹窄伴眼部缺血性錶現患者的臨床特徵和治療效果。方法迴顧性分析齊齊哈爾醫學院第五臨床醫學院眼科2011年12月至2012年12月期間71例(71隻眼)頸內動脈狹窄伴眼部缺血性錶現患者的臨床資料,描述患者頸內動脈狹窄伴眼部缺血性情況。因為對療效數據為有序數據,故採用Kruskal-Wallis H秩和檢驗的方法進行比較。以P<0.05為差異有統計學意義。噹差異有統計學意義時,對3組之間的療效進行兩兩比較。結果71例患者中,一過性黑矇者33例(33隻眼),眼前閃光者25例(25隻眼),眼部紅腫伴有眼眶週圍疼痛者23例(23隻眼),複視者7例(7隻眼),視力下降者4例(4隻眼)。27例眼部缺血性疾病確診患者中,缺血性視神經病變者8例(8隻眼),眼部缺血綜閤徵者55例(55隻眼),視網膜中央分支動脈阻塞者6例(6隻眼),視網膜齣血者4例(4隻眼),眼外肌痳痺者3例(3隻眼),新生血管性青光眼1例(1隻眼),頸內動脈狹窄程度和眼部缺血性疾病的髮生率呈高度正相關。單純藥物治療後顯效者2隻眼(13.3%),有效者4隻眼(26.7%),無效者9隻眼(60.0%),總有效率40.0%;頸內動脈內膜切除術後顯效者10隻眼(43.5%),有效者11隻眼(47.8%),無效者2隻眼(8.7%),總有效率91.3%;頸內動脈支架置入術後顯效者11隻眼(47.8%),有效者8隻眼(34.8%),無效者4隻眼(17.4%),總有效率82.6%,採取頸內動脈支架置入術和頸內動脈內膜切除術的治療效果明顯優于單純藥物治療,差異有統計學意義(Hc=9.60,7.68;P=0.002,0.006)。結論頸內動脈狹窄伴眼部缺血性錶現的患者,臨床特徵較為多樣,可齣現多種眼部缺血性疾病,行頸內動脈支架置入術或頸內動脈內膜切除術,可穫得較好的臨床治療效果。
목적:탐토경내동맥협착반안부결혈성표현환자적림상특정화치료효과。방법회고성분석제제합이의학원제오림상의학원안과2011년12월지2012년12월기간71례(71지안)경내동맥협착반안부결혈성표현환자적림상자료,묘술환자경내동맥협착반안부결혈성정황。인위대료효수거위유서수거,고채용Kruskal-Wallis H질화검험적방법진행비교。이P<0.05위차이유통계학의의。당차이유통계학의의시,대3조지간적료효진행량량비교。결과71례환자중,일과성흑몽자33례(33지안),안전섬광자25례(25지안),안부홍종반유안광주위동통자23례(23지안),복시자7례(7지안),시력하강자4례(4지안)。27례안부결혈성질병학진환자중,결혈성시신경병변자8례(8지안),안부결혈종합정자55례(55지안),시망막중앙분지동맥조새자6례(6지안),시망막출혈자4례(4지안),안외기마비자3례(3지안),신생혈관성청광안1례(1지안),경내동맥협착정도화안부결혈성질병적발생솔정고도정상관。단순약물치료후현효자2지안(13.3%),유효자4지안(26.7%),무효자9지안(60.0%),총유효솔40.0%;경내동맥내막절제술후현효자10지안(43.5%),유효자11지안(47.8%),무효자2지안(8.7%),총유효솔91.3%;경내동맥지가치입술후현효자11지안(47.8%),유효자8지안(34.8%),무효자4지안(17.4%),총유효솔82.6%,채취경내동맥지가치입술화경내동맥내막절제술적치료효과명현우우단순약물치료,차이유통계학의의(Hc=9.60,7.68;P=0.002,0.006)。결론경내동맥협착반안부결혈성표현적환자,림상특정교위다양,가출현다충안부결혈성질병,행경내동맥지가치입술혹경내동맥내막절제술,가획득교호적림상치료효과。
Objective To investigate the clinical characteristics and therapeutic effect of carotid artery stenosis associated with ocular ischemic appearance.Methods A total of 71 cases ( 71 eyes ) of carotid artery stenosis associated with ocular ischemia from Dec.2011 to Dec.2012 in Department of Ophthalmology,the Fifth Affiliated Hospital of Qiqihar Medicical University were retrospectively analyzed. The degree of carotid artery stenosis and ocular ischemic appearance were described.Therapeutic effect was ordered data and it was evaluated by Kruskal-Wallis H rank sum test.Difference was statistically significant when P<0.05.Results Ocular symptoms were observed in all 71 cases, including amaurosis fugax in 33 cases (33 eyes),flash before the eye in 25 cases (25 eyes),periorbital swelling and pain in 23 cases (23 eyes),diplopia in 7 cases (7 eyes) and vision loss in 4 cases (4 eyes).There were 27 cases diagnosed with ocular ischemic diseases, including ischemic optic neuropathy in 8 cases ( 8 eyes ) ocular ischemic syndrome in 5cases (5 eyes),central or branch retinal artery occlusion in 6 cases (6 eyes), retinal hemorrhage in 4 patients ( 4 eyes ) , extraocular muscle paralysis in 3 patients ( 3 eyes ) and neovascular glaucoma in 1 patients (1 eye).There was a high-positive correlation between the degree of carotid stenosis and the incidence of ocular ischemic disease.In simple drug treatment group, 2 eyes ( 13.3%) were markedly effective,4 eyes (26.7%) were effective and 9 eyes (60.0%) were in vain.The total efficiency was 40.0%.In carotid endarterectomy group,10 eyes (43.5%) were markedly effective,11 eyes (47.8%) were effective and 2 eyes (8.7%) were in vain.The total efficiency was 91.3%.In carotid artery stenting group,11 eyes (47.8%) were markedly effective,8 eyes (34.8%) were effective and 4 eyes (17.4%) were in vain.The total efficiency was 82.6%.The theraputic effect of carotid artery stenting and carotid endarterectomy was significantly better than that of drug treatment alone, the difference was statistically significant (Hc=9.60,7.68;P=0.002,0.006).Conclusions Cartery stenosis associated with ocular ischemic appearance has diversified clinical manifestations.It can be complicated by many kinds of ocular ischemic diseases.Carotid artery stenting and carotid endarterectomy were effective treatment.