中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2014年
18期
7-7,9
,共2页
吴庆锋%蒋健昌%苏珊娜%莫金灿%李晓玲%苏保育%张俊成
吳慶鋒%蔣健昌%囌珊娜%莫金燦%李曉玲%囌保育%張俊成
오경봉%장건창%소산나%막금찬%리효령%소보육%장준성
帕利哌酮%奥氮平%瘦素%胰岛素
帕利哌酮%奧氮平%瘦素%胰島素
파리고동%오담평%수소%이도소
Paliperidone%Olanzapine%Leptin%Insulin
目的:探讨帕利哌酮与奥氮平对首发精神分裂症患者血浆瘦素和胰岛素水平的影响。方法首发精神分裂症患者60例,随机分为帕利哌酮治疗组(30例)和奥氮平治疗组(30例),30例健康成人为对照组,治疗组在治疗前和治疗后6周末测定血浆瘦素和胰岛素水平。结果治疗后奥氮平组瘦素含量较治疗前明显升高,治疗前后胰岛素水平奥氮平组比较有统计学差异,治疗后奥氮平组BMI与治疗前比较有统计学意义,奥氮平组BMI增加值与帕利哌酮组有统计学差异(P<0.05)。结论奥氮平对血浆瘦素、胰岛素水平和BMI均有明显影响,而帕利哌酮则影响不明显。
目的:探討帕利哌酮與奧氮平對首髮精神分裂癥患者血漿瘦素和胰島素水平的影響。方法首髮精神分裂癥患者60例,隨機分為帕利哌酮治療組(30例)和奧氮平治療組(30例),30例健康成人為對照組,治療組在治療前和治療後6週末測定血漿瘦素和胰島素水平。結果治療後奧氮平組瘦素含量較治療前明顯升高,治療前後胰島素水平奧氮平組比較有統計學差異,治療後奧氮平組BMI與治療前比較有統計學意義,奧氮平組BMI增加值與帕利哌酮組有統計學差異(P<0.05)。結論奧氮平對血漿瘦素、胰島素水平和BMI均有明顯影響,而帕利哌酮則影響不明顯。
목적:탐토파리고동여오담평대수발정신분렬증환자혈장수소화이도소수평적영향。방법수발정신분렬증환자60례,수궤분위파리고동치료조(30례)화오담평치료조(30례),30례건강성인위대조조,치료조재치료전화치료후6주말측정혈장수소화이도소수평。결과치료후오담평조수소함량교치료전명현승고,치료전후이도소수평오담평조비교유통계학차이,치료후오담평조BMI여치료전비교유통계학의의,오담평조BMI증가치여파리고동조유통계학차이(P<0.05)。결론오담평대혈장수소、이도소수평화BMI균유명현영향,이파리고동칙영향불명현。
Objective To explore the effects paliperidone and olanzapine on plasma leptin and insulin in first-episode schizophrenic patients. Methods Sixty first-episode schizophrenics were randomly divided into two groups, which were treated with olanzapine and paliperidone respectively. The plasma leptin and insulin concentration was measured with radioimmunoassay pretreatment and 6 weeks post-treatment. Results Plasma leptin level of post-treatment increased compared with that of pre-treatment in olanzapine group, plasma insulin level of post-treatment increased compared with that of pre-treatment in olanzapine group, BMI after treatment increased compared with that before treatmentres in olanzapine group (P<0.05). Conclusion Olanzapine have significant effects on plasma leptin and insulin concentration and BMI, but paliperidone has no obvious effect on plasma leptin and insulin levels and BMI.