CAJ | 학술논문

目的为降低辐射剂量,探讨淋巴瘤化疗后采用受侵区域PET-CT扫描评价疗效的可行性.方法回顾性分析53例化疗前、后均行全身PET-CT扫描的淋巴瘤初诊患者.将化疗前PET-CT所示的淋巴瘤侵犯范围定义为受侵区域,化疗后假设采用受侵区域PET-CT扫描,比较其与全身PET-CT扫描在疗效评价方面的差异.对全身和受侵区域PET-CT扫描疗效评价结果一致者,比较其有效剂量和扫描时间的差异.结果在评价淋巴瘤化疗后疗效方面,全身PET-CT扫描示37例达到完全缓解(CR)、13例部分缓解(PR)、3例进展(PD),受侵区域PET-CT示37例达到CR、14例PR、2例PD.37例CR者全身和受侵区域PET-CT扫描的有效剂量分别为(15.0±1.7)和(12.0±2.5)mSv(Z=-5.307,P＜0.05)、扫描时间分别为(19.5±2.6)与(11.3±4.4)s(Z=-5.324,P＜0.05).结论化疗后达到CR者行受侵区域PET-CT扫描,其疗效与全身PET-CT扫描相同,减少了PET-CT扫描的有效剂量和时间.化疗后PR或PD者受侵区域PET-CT扫描的疗效评价结果与全身扫描不同,应行全身PET-CT扫描评价化疗后疗效.
목적 위강저복사제량,탐토림파류화료후채용수침구역PET-CT소묘평개료효적가행성.방법 회고성분석53례화료전、후균행전신PET-CT소묘적림파류초진환자.장화료전PET-CT소시적림파류침범범위정의위수침구역,화료후가설채용수침구역PET-CT소묘,비교기여전신PET-CT소묘재료효평개방면적차이.대전신화수침구역PET-CT소묘료효평개결과일치자,비교기유효제량화소묘시간적차이.결과 재평개림파류화료후료효방면,전신PET-CT소묘시37례체도완전완해(CR)、13례부분완해(PR)、3례진전(PD),수침구역PET-CT시37례체도CR、14례PR、2례PD.37례CR자전신화수침구역PET-CT소묘적유효제량분별위(15.0±1.7)화(12.0±2.5)mSv(Z=-5.307,P＜0.05)、소묘시간분별위(19.5±2.6)여(11.3±4.4)s(Z=-5.324,P＜0.05).결론 화료후체도CR자행수침구역PET-CT소묘,기료효여전신PET-CT소묘상동,감소료PET-CT소묘적유효제량화시간.화료후PR혹PD자수침구역PET-CT소묘적료효평개결과여전신소묘불동,응행전신PET-CT소묘평개화료후료효.
Objective To assess PET-CT scanning limited to involved sites in postchemotherapy lymphoma and explore possible radiation dose reductions.Methods Fifty-three lymphoma patients with prechemotherapy and postchemotherapy whole-body PET-CT were analyzed retrospectively.The involved sites were determined on prechemotherapy PET-CT scanning.Whole-body PET-CT scanning and hypothetical PET-CT limited to involved sites were compared in assessing clinical response to chemotherapy.The potential reductions in effective dose and total acquisition time achieved with PET-CT scanning limited to involved sites were calculated.Results Whole-body PET-CT scanning revealed CR in 37 cases,PR in 13 cases and PD in 3 cases in postchemotherapy lymphoma patients,while PET-CT scanning limited to involved sites revealed CR in 37 cases,PR in 14 cases and PD in 2 cases.The mean effective dose was(15.0 ± 1.7)mSv for per patients of CR with whole-body PET-CT scanning,and was (12.0 ± 2.5)mSv for per patients of CR with PET-CT scanning limited in involved sites(Z=-5.307,P＜0.05).The mean acquisition time was(19.5 ±2.6)s for per patients of CR with whole-body PET-CT scanning,and(11.3 ± 4.4)s for per patient of CR with PET-CT scanning limited in involved sites(Z=-5.324,P＜0.05).Conclusions Response assessment with PET-CT scanning limited in involved sites has good agreement with whole-body PET-CT scanning in postchemotherapy lymphoma patients with CR.Lymphoma patients with CR may benefit from reduced radiation dose and total acquisition time.PET-CT scanning limited in involved sites is not advisable in patients with PR or PD for poor agreement with whole-body PET-CT scanning in response assessment.