CAJ | 학술논문

目的：探讨HBV感染抗病毒治疗过程中发生肝细胞癌（HCC）的原因和诊断方法。方法回顾性分析24例HBV感染（肝炎后肝硬化者18例、CHB者6例）抗病毒治疗过程中发生HCC的病例，分析其发生原因及诊断方法。结果 HBV感染抗病毒过程中发生HCC常见。患肝病时间、男性、抗病毒治疗效果不佳（或发生病原学突破）、吸烟、饮酒、糖尿病是抗病毒治疗过程中发生HCC常见原因。肝硬化发展至肝癌常无症状，慢性肝炎发展至肝癌常有肝区不适、生物化学检测结果异常、HBV载量变化。AFP、彩色多普勒超声、CT联合检查基本可以完成HCC的临床诊断，必要时辅以肝脏病理学检查。结论HBV感染抗病毒过程中发生HCC常见，提高认识有利于早期发现HCC。
목적：탐토HBV감염항병독치료과정중발생간세포암（HCC）적원인화진단방법。방법회고성분석24례HBV감염（간염후간경화자18례、CHB자6례）항병독치료과정중발생HCC적병례，분석기발생원인급진단방법。결과 HBV감염항병독과정중발생HCC상견。환간병시간、남성、항병독치료효과불가（혹발생병원학돌파）、흡연、음주、당뇨병시항병독치료과정중발생HCC상견원인。간경화발전지간암상무증상，만성간염발전지간암상유간구불괄、생물화학검측결과이상、HBV재량변화。AFP、채색다보륵초성、CT연합검사기본가이완성HCC적림상진단，필요시보이간장병이학검사。결론HBV감염항병독과정중발생HCC상견，제고인식유리우조기발현HCC。
Objective To investigat causes and diagnosis method of hepatocellular carcinoma that hepatitis B virus infection was treated in the process of antiviral. Methods The causes and diagnosis method was retrospective analysed of 24 cases of hepatocellular carcinoma (18 cases of posthepatitic liver cirrhosis, 6 cases of chronic hepatitis B) that hepatitis B virus infection was treated in the process of antiviral. Results The hepatocellular carcinoma was more common that hepatitis B virus infection was treated in the process of antiviral. The the most common cause of hepatocellular carcinoma happened that hepatitis B virus infection was treated in the process of antiviral is the time of liver disease, male, poor effect of antiviral treatment (or pathogenic breakthrough), diabetes. It is often asymptomatic from liver cirrhosis to hepatocellular carcinoma. The progression of chronic hepatitis to hepatocellular carcinoma often has liver area unwell, biochemical changes, changes in the amount of the hepatitis B virus. Clinical diagnosis of hepatocellular carcinoma was completed with alpha-fetoprotein (AFP), color doppler ultrasound, CT, and the liver pathology was implemented. Conclusions The hepatocellular carcinoma was more common that hepatitis B virus infection was treated in the process of antiviral. Raising awareness is helpful for early diagnosis of HCC.