CAJ | 학술논문

目的：探讨三氧化二砷（As2O3）治疗晚期原发性肝癌（PLC）的临床价值。方法将48例患者随机分为治疗组（26例）和对照组（22例）。两组患者在保肝、抗病毒、支持对症等治疗基础上，治疗组加用As2O310 mg，10%葡萄糖注射液500 ml，每日1次静脉输注，每2周为1个疗程，间隔2周进行下一个疗程，共2个疗程，观察结束复查并进行疗效评估。结果两组患者观察结束的客观有效率、获益率分别为0.0%、19.2%（P=0.0376）和22.8%、53.8%（P=0.0083），两组患者生活质量改善和稳定率分别为31.8%和65.4%（P=0.0291）。结论As2O3治疗晚期PLC具有一定的临床价值，对于肝功能差且无法耐受其他治疗的PLC患者，As2O3仍不失是一种较有效的治疗手段。
목적：탐토삼양화이신（As2O3）치료만기원발성간암（PLC）적림상개치。방법장48례환자수궤분위치료조（26례）화대조조（22례）。량조환자재보간、항병독、지지대증등치료기출상，치료조가용As2O310 mg，10%포도당주사액500 ml，매일1차정맥수주，매2주위1개료정，간격2주진행하일개료정，공2개료정，관찰결속복사병진행료효평고。결과량조환자관찰결속적객관유효솔、획익솔분별위0.0%、19.2%（P=0.0376）화22.8%、53.8%（P=0.0083），량조환자생활질량개선화은정솔분별위31.8%화65.4%（P=0.0291）。결론As2O3치료만기PLC구유일정적림상개치，대우간공능차차무법내수기타치료적PLC환자，As2O3잉불실시일충교유효적치료수단。
Objective To investigate the effect of arsenic trioxide (As2O3) in treatment of advanced primary liver carcinoma (PLC). Methods Total of 48 cases of advanced PLC were randomly divided into the treatment group (26 cases) and control group (22 cases). The two groups received basic hepatoprotective, antiviral, symptomatic of the treatment group was added with As2O3 10 mg, 10%glucose injection 500 ml, intravenous drip once a day, every two weeks for one courses, two weeks apart, for a course of treatment, a total of two courses. An observation is checked and curative effect evaluation. Results The two groups of patients were observed at the end of the objective efifciency, beneift rate were 0%, 19.2%and 22.8%(P=0.0376), 53.8%(P = 0.0083), two groups of patients and improve quality of life, stable rate were 31.8%and 65.4%(P=0.0291). Conclusions As2O3 treatment has a certain clinical value for advanced PLC, liver function is poor, unable to tolerate other treatment of patients with PLC, As2O3 is a more effective treatment.