CAJ | 학술논문

外周神经浸润（PNI）与多种类型肿瘤转移、复发关系密切，是独立预后不良因素。本文从明确PNI 概念开始，综述目前 PNI 分子和病理机制、体外内模型建立等研究进展，旨在更深入地了解PNI 在肿瘤转移、复发中的作用，为进一步研究 PNI 机制及开发靶向 PNI 治疗策略奠定基础。
외주신경침윤（PNI）여다충류형종류전이、복발관계밀절，시독립예후불량인소。본문종명학PNI 개념개시，종술목전 PNI 분자화병리궤제、체외내모형건립등연구진전，지재경심입지료해PNI 재종류전이、복발중적작용，위진일보연구 PNI 궤제급개발파향 PNI 치료책략전정기출。
Perineural invasion (PNI) has been reported to be closely related to the metastasis and recurrence in various cancers..For many of these malignancies,.PNI is emerging as an independent risk factor for poor prognosis. In the present study , a clear definition of PNI was laid out , and then the authors summarized current theories on the molecular mechanism and pathogenesis of PNI. In addition, current research in vitro and in vivo models for PNI were also introduced. The objectives of this review were to highlight the PNI status in predicting cancer metastasis and recurrence , as well as lead to advancements in the understanding and target therapy of this pathological entity.