CAJ | 학술논문

目的：检测结直肠癌术后患者血清中糖链抗原724（CA724）、癌胚抗原（CEA）的表达水平并观察两者的相关性。方法收集手术治疗后复发的结直肠癌患者38例作为观察组，无复发或转移的结直肠癌术后患者38例作为对照组，晨起空腹抽血，电化学发光法测定血清 CEA、CA724含量，同时行 Pearson 相关系数检验 CA724与CEA 的相关性。结果观察组血清 CA724、EA 表达水平较对照组均显著升高（P＜0．01），差异存在统计学意义；观察组 CA724、CEA 阳性率较对照组均升高（P＜0．05），差异存在统计学意义；且两者显著相关，相关系数 r＝0．622（P＜0．01）。结论结直肠癌患者外周血清中CA724、CEA 的含量显著升高，并且血清中 CA724水平与 CEA 水平显著相关。 CA724作为结直肠癌术后复查指标的价值值得进一步研究。
목적：검측결직장암술후환자혈청중당련항원724（CA724）、암배항원（CEA）적표체수평병관찰량자적상관성。방법수집수술치료후복발적결직장암환자38례작위관찰조，무복발혹전이적결직장암술후환자38례작위대조조，신기공복추혈，전화학발광법측정혈청 CEA、CA724함량，동시행 Pearson 상관계수검험 CA724여CEA 적상관성。결과관찰조혈청 CA724、EA 표체수평교대조조균현저승고（P＜0．01），차이존재통계학의의；관찰조 CA724、CEA 양성솔교대조조균승고（P＜0．05），차이존재통계학의의；차량자현저상관，상관계수 r＝0．622（P＜0．01）。결론결직장암환자외주혈청중CA724、CEA 적함량현저승고，병차혈청중 CA724수평여 CEA 수평현저상관。 CA724작위결직장암술후복사지표적개치치득진일보연구。
Objective To detect the serum carbohydrate antigen 724 (CA724) and embryonic antigen (CEA) expression levels in colorectal cancer patients and observe the correlation between both of them. Methods Thirty-eight colorectal cancer patients as observer group; and 38 patients without recurrence or metastasis of cancer as control group. After taking the fasting blood , the serum levels of CA724 and CEA were detected using electrochemiluminescence method. Besides , the correlation of CA724 with CEA was tested using Pearson correlation coefficient. Results The serum levels of CA724 and CEA were higher in colorectal cancer patients than those in the control group. And the differences were statistically significant (P<0.01). In 76 patients, the serum levels of CA724 and CEA were significantly correlated, (correlation coefficient r=0.622, P<0.01). Conclusion CA724 and CEA are significantly increased in the serum of advanced colorectal cancer patients. .And the serum level of CA724 is significantly correlated with the serum level of CEA in colorectal cancer patients. .CA724 as an follow-up indicator of colorectal cancer after operation of is worthy of further study.