CAJ | 학술논문

目的：探讨右美托咪啶（ DEX ）用于腹部手术患者的全麻效果、术后恢复质量及安全性。方法全身麻醉腹部手术患者91例随机分为试验组（44例）和对照组（47例）。对照组于麻醉诱导前15 min静脉滴注生理盐水15 mL，试验组静脉滴注DEX负荷剂量0.5μg· kg-1，随后以0.25μg· kg-1· h-1的速率输注直至拔除气管插管。观察比较2组患者自主呼吸恢复时间、苏醒时间、拔管时间及不良反应发生率。结果试验组麻醉苏醒期VRS镇痛评分为（2.4±0.8），对照组为（3.7±1.1），试验组显著低于对照组（P＜0.05）；苏醒期躁动及呛咳不良反应发生率，试验组显著低于对照组（ P＜0.05）；2组患者自主呼吸恢复时间、拔除气管导管时间及苏醒时间差别无统计学意义（ P＞0.05）。结论 DEX用于腹部手术患者可显著增强全身麻醉效果，降低苏醒期不良反应发生率。
목적：탐토우미탁미정（ DEX ）용우복부수술환자적전마효과、술후회복질량급안전성。방법전신마취복부수술환자91례수궤분위시험조（44례）화대조조（47례）。대조조우마취유도전15 min정맥적주생리염수15 mL，시험조정맥적주DEX부하제량0.5μg· kg-1，수후이0.25μg· kg-1· h-1적속솔수주직지발제기관삽관。관찰비교2조환자자주호흡회복시간、소성시간、발관시간급불량반응발생솔。결과시험조마취소성기VRS진통평분위（2.4±0.8），대조조위（3.7±1.1），시험조현저저우대조조（P＜0.05）；소성기조동급창해불량반응발생솔，시험조현저저우대조조（ P＜0.05）；2조환자자주호흡회복시간、발제기관도관시간급소성시간차별무통계학의의（ P＞0.05）。결론 DEX용우복부수술환자가현저증강전신마취효과，강저소성기불량반응발생솔。
Objective To evaluate the clinical efficacy and safety of dexmedetomidine ( DEX ) on patients undergoing abdominal surgery who received general anesthesia and on quality of post -surgery recovery.Methods Ninety-one patients who were planed for abdominal surgery with general anesthesia were randomly divided into treatment group ( n=44 ) and control group ( n=47 ) with random number table.Patients in control group were given saline 15 mL 15 min prior general anesthesia.And patients in treatment group were given DEX 0.5 μg· kg -1 and then 0.25 μg· kg -1 · h-1 in the procedure of operation.Spontaneous breath-ing, awaking time, extubation time and side effects were compared be-tween two groups.Results The VRS analgesic score in treatment group was much lower than that in control ( P<0.05 ).The incidence rate of agitation bucking in treatment group was much lower than that in control group ( P<0.05 ).But spontaneous breathing time , awaking time and extubation time showed no statistical difference between the two groups ( P>0.05).Conclusion DEX can significantly reduce the risk of de-veloping agitation , bucking and improve the general anesthesia efficacy in patients receiving abdominal surgery who underwent general anesthesia.