CAJ | 학술논문

为验证新药清营口服液的安全性和有效性，进行了Wistar大鼠的安全性试验和SPF鸡临床疗效试验。在40～10 g/kg b．w．剂量范围内，经口给予清营口服液30 d后，检查Wistar大鼠的一般生理状态及血液生理、生化指标，并进行病理解剖及病理组织学检查。结果表明清营口服液各剂量组所有检测指标，与阴性对照组无显著差异（P＞0．05），且对Wistar大鼠的生长发育未产生影响，较长期重复应用无亚急性毒性，说明该药安全性较强：通过对比清营口服液试验组和氟苯尼考对照组对SPF鸡的疗效发现清营口服液组能够对体内注射的大肠杆菌起到较好的抑菌和杀菌效果，从试验鸡的死亡率和分菌结果可以看出清营口服液总体预防和治疗效果好于氟苯尼考，说明清营口服液有较好的临床抗菌效果。
위험증신약청영구복액적안전성화유효성，진행료Wistar대서적안전성시험화SPF계림상료효시험。재40～10 g/kg b．w．제량범위내，경구급여청영구복액30 d후，검사Wistar대서적일반생리상태급혈액생리、생화지표，병진행병리해부급병리조직학검사。결과표명청영구복액각제량조소유검측지표，여음성대조조무현저차이（P＞0．05），차대Wistar대서적생장발육미산생영향，교장기중복응용무아급성독성，설명해약안전성교강：통과대비청영구복액시험조화불분니고대조조대SPF계적료효발현청영구복액조능구대체내주사적대장간균기도교호적억균화살균효과，종시험계적사망솔화분균결과가이간출청영구복액총체예방화치료효과호우불분니고，설명청영구복액유교호적림상항균효과。
The tests were conducted to confirm the safety and clinical efficacy of Qingying Oral Liquid with Wistar rats and SPF chicken .The general physical status , physiological and biochemical indexes of blood, pathological anatomy and histopathologic examination of the Wistar rats were analyzed after 30 days of oral administration in the range of 4~10 g/kg b.w.The results showed that the detection indexes were all in the normal range and had no significant difference compared to the control group ( P>0 .05 ) .Qingying Oral Liquid was more safety due to no effect on growth and development and no subacute toxity to Wistar rats after longer term repeated application .Compared to florfenicol , Qingying Oral Liquid exhibited antibacterial and bactericidal activities to Escherichia coli.The prevention and treatment effect against Escherichia coli of Qingy-ing Oral Liquid was better than florfenicol taking mortality and bacterial count into account .