CAJ | 학술논문

目的：对比分析东莞市不育青年男性与生育正常青年男性各项精子功能指标。方法回顾性分析本院120例年龄在25~34岁的青年男性患者，依据生育功能差异将其分为不育组(60例)，规律性生活未避孕1年而不孕；对照组(60例)，1年内令配偶正常受孕。比较两组的精子密度，精子活力参数[包括平均曲线运动速度(VCL)、平均路径运动速度(VAP)及精子平均鞭打频率(BCF)]，精子运动方式参数[包括运动直线性(LN)、运动摆动性(WOB)、运动前向性(STR)及运动侧摆幅度(ALH)]，精子形态指标，精子DNA碎片指数(DFI)，顶体酶活性和生育力指数(FI)的差异。结果不育组的精子密度、精子活力参数(VCL、VAP及BCF)、精子运动方式参数(LN、WOB、STR及ALH)与对照组比较，差异无统计学意义(P>0.05)；不育组的正常形态精子百分率、DFI、顶体酶活性及FI显著低于对照组，差异有统计学意义(P<0.05)。结论东莞市不育青年男性的各项精子功能指标显著较生育正常青年男性差。
목적：대비분석동완시불육청년남성여생육정상청년남성각항정자공능지표。방법회고성분석본원120례년령재25~34세적청년남성환자，의거생육공능차이장기분위불육조(60례)，규률성생활미피잉1년이불잉；대조조(60례)，1년내령배우정상수잉。비교량조적정자밀도，정자활력삼수[포괄평균곡선운동속도(VCL)、평균로경운동속도(VAP)급정자평균편타빈솔(BCF)]，정자운동방식삼수[포괄운동직선성(LN)、운동파동성(WOB)、운동전향성(STR)급운동측파폭도(ALH)]，정자형태지표，정자DNA쇄편지수(DFI)，정체매활성화생육력지수(FI)적차이。결과불육조적정자밀도、정자활력삼수(VCL、VAP급BCF)、정자운동방식삼수(LN、WOB、STR급ALH)여대조조비교，차이무통계학의의(P>0.05)；불육조적정상형태정자백분솔、DFI、정체매활성급FI현저저우대조조，차이유통계학의의(P<0.05)。결론동완시불육청년남성적각항정자공능지표현저교생육정상청년남성차。
Objective To compare the sperm functions to infertility and normal fertility of youth male in Dongguan city. Methods A total of 120 youth male whose age range was from 25 years to 34 years were collected to retrospectively analyze,and were divided into infertility group (60 cases,regular sexual life without contraception one year) and control group (60 cases,spouse pregnancy in one year) according to the reproductive function variation.The indexes of sperm concentration,sperm motility parameters [including the mean velocity of curvilinear (VCL),the velocity of average path (VAP),beat cross frequency (BCF)],sperm motion parameters [including the linear movement (LN),wobble movement (WOB),mean straightness (STR) and amplitude of lateral head displacement (ALH)],sperm morphology index,sperm DNA fragmentation index (DFI),acrosomal enzyme activities and fertility index (FI) were compared between two groups. Re-sults Compared with control group,the indexes of sperm concentration,sperm motility parameters (VCL,VAP and BCF), sperm motion parameters (LN,WOB,STR and ALH) in research group had no significant different (P>0.05),but the per-cent of normal morphology sperm,DFI,acrosomal enzyme activities and FI in research group was lower,the difference was significant (P<0.05). Conclusion The indexes of sperm functions to infertility youth male in Dongguan city are poorer than that to normal fertility of youth male.