中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2014年
18期
92-94
,共3页
糖尿病肾病%肾纤维化%血瘀证%人基质金属蛋白酶组织抑制因子-1
糖尿病腎病%腎纖維化%血瘀證%人基質金屬蛋白酶組織抑製因子-1
당뇨병신병%신섬유화%혈어증%인기질금속단백매조직억제인자-1
Diabetic nephropathy%Renal fibrosis%Blood stasis syndrome%Tissue inhibitors to metalloproteinase-1
目的：分析纤维化指标在糖尿病肾病(DN)血瘀证与非血瘀证间表达水平的差异，验证“血瘀证是导致DN肾纤维化的主要病机”的中医理论。方法依照中医辨证将本院60例以DN患者分为血瘀证组(A组)与非血瘀证组(B组)，另设健康对照组(C组)，检测各组的纤维化相关指标，并进行统计分析。结果 A、B组的血清Ⅲ型前胶原(PCⅢ)、透明质酸(HA)、人基质金属蛋白酶组织抑制因子-1(TIMP-1)含量与健康对照组比较，差异有统计学意义(P<0.01)，A、B组的TIMP-1含量比较，差异有统计学意义(P<0.01)。结论 DN血瘀证组的纤维化程度重，与中医理论认为“血瘀是导致DN肾纤维化的主要病机”相符。
目的：分析纖維化指標在糖尿病腎病(DN)血瘀證與非血瘀證間錶達水平的差異，驗證“血瘀證是導緻DN腎纖維化的主要病機”的中醫理論。方法依照中醫辨證將本院60例以DN患者分為血瘀證組(A組)與非血瘀證組(B組)，另設健康對照組(C組)，檢測各組的纖維化相關指標，併進行統計分析。結果 A、B組的血清Ⅲ型前膠原(PCⅢ)、透明質痠(HA)、人基質金屬蛋白酶組織抑製因子-1(TIMP-1)含量與健康對照組比較，差異有統計學意義(P<0.01)，A、B組的TIMP-1含量比較，差異有統計學意義(P<0.01)。結論 DN血瘀證組的纖維化程度重，與中醫理論認為“血瘀是導緻DN腎纖維化的主要病機”相符。
목적：분석섬유화지표재당뇨병신병(DN)혈어증여비혈어증간표체수평적차이，험증“혈어증시도치DN신섬유화적주요병궤”적중의이론。방법의조중의변증장본원60례이DN환자분위혈어증조(A조)여비혈어증조(B조)，령설건강대조조(C조)，검측각조적섬유화상관지표，병진행통계분석。결과 A、B조적혈청Ⅲ형전효원(PCⅢ)、투명질산(HA)、인기질금속단백매조직억제인자-1(TIMP-1)함량여건강대조조비교，차이유통계학의의(P<0.01)，A、B조적TIMP-1함량비교，차이유통계학의의(P<0.01)。결론 DN혈어증조적섬유화정도중，여중의이론인위“혈어시도치DN신섬유화적주요병궤”상부。
Objective To analyze the difference of expression level of fibrosis indexes between blood stasis syndrome and none-blood stasis syndrome in diabetic nephropathy (DN) to verify the theory of traditional Chinese medicine (TCM) that"blood stasis is the main pathogenesis of renal fibrosis in DN". Methods According to syndrome differenti-ation of TCM,60 patients with DN in our hospital were divided into the blood stasis syndrome group (the group A) and the none-blood stasis syndrome group (the group B),another healthy control group (the group C) was set up,fibrosis re-lated indicators of all samples were tested,and the data was analyzed. Results All DN patients’serum HA,PCⅢ,TIMP-1 were higher than those the healthy control group (P<0.01),The difference of TIMP-1 level between between the blood stasis syndrome and the blood stasis syndrome group was significant (P<0.01). Conclusion The degree of fibrosis was heavy in blood stasis syndrome group of DN,it matches with the theory that "blood stasis is the main pathogenesis of renal fibrosis in DN".
