CAJ | 학술논문

目的探讨吡格列酮联合二甲双胍治疗老年2型糖尿病的临床疗效。方法选取我院2009年3月~2013年3月收治的120例老年糖尿病患者的临床资料，随机分为治疗组(60例)和对照组(60例),对照组采用常规治疗，治疗组患者在对照组治疗的基础上联合吡格列酮治疗，连续治疗12 w，观察两组患者空腹血糖(FBG)、餐后2 h血糖(PBG)、胰岛素敏感指数、肾功能改变情况。结果在治疗12 w之后，治疗组患者的空腹血糖和餐后2 h血糖改善明显优于对照组患者，两组患者疗效比较差异有统计学意义(P<0.05)。治疗组患者胰岛素敏感指数低于对照组，两组患者比较差异有统计学意义(P<0.05)，治疗组患者UAER及ET-1均显著低于对照组患者，两组患者比较差异有统计学意义(<0.05)。结论吡格列酮联合二甲双胍治疗2型糖尿病，降糖效果好，可改善患者的胰岛素抵抗，减少微量蛋白的排泄，疗效满意值得在临床推广。
목적탐토필격렬동연합이갑쌍고치료노년2형당뇨병적림상료효。방법선취아원2009년3월~2013년3월수치적120례노년당뇨병환자적림상자료，수궤분위치료조(60례)화대조조(60례),대조조채용상규치료，치료조환자재대조조치료적기출상연합필격렬동치료，련속치료12 w，관찰량조환자공복혈당(FBG)、찬후2 h혈당(PBG)、이도소민감지수、신공능개변정황。결과재치료12 w지후，치료조환자적공복혈당화찬후2 h혈당개선명현우우대조조환자，량조환자료효비교차이유통계학의의(P<0.05)。치료조환자이도소민감지수저우대조조，량조환자비교차이유통계학의의(P<0.05)，치료조환자UAER급ET-1균현저저우대조조환자，량조환자비교차이유통계학의의(<0.05)。결론필격렬동연합이갑쌍고치료2형당뇨병，강당효과호，가개선환자적이도소저항，감소미량단백적배설，료효만의치득재림상추엄。
Objective To investigate the pioglitazone joint metformin treatment of senile type 2 clinical curative ef ect. Methods Select our March 2009~in March 2010 were 120 cases of elderly patients with diabetes, the clinical data were randomly divided into the treatment group (n=60) and the control group (n=60), were treated by conventional treatment, the treatment groups of patients in the control group treatment based on joint pioglitazone treatment, continuous treatment 12 weeks, observe the two groups were fasting plasma glucose (FBG) and 2-hr plasma glucose (PBG), insulin sensitivity index, kidney change. Results In the treatment of 12 weeks after treatment groups of patients fasting glucose and 2-hr plasma glucose improve significantly bet er in patients, two groups of patients was statistical y significant ef ect comparative differences ( < 0.05). The treatment group was lower in patients with insulin sensitivity index, two groups of patients were compared with a dif erence was statistical y significant ( < 0.05), the treatment group patients UAER and ET - 1 were significantly lower than the control group patients, two groups were comparative dif erences are statistical y significant ( <0.05).Conclusion Pioglitazone joint metformin treatment for type 2 diabetes, hypoglycemic effect is good, can improve patients with insulin resistance, reduce trace protein excretion, and the results were satisfactory worth in clinical promotion.