CAJ | 학술논문

目的观察原发性视网膜色素变性(RP)患眼短波长自身荧光(SW-AF)和近红外自身荧光(NIR-AF)特征以及与视野改变的相关性.方法临床检查确诊的原发性RP患者12例24只眼纳入研究.其中,男性9例18只眼,女性3例6只眼.年龄15～69岁,平均年龄(35.33±15.03)岁.均行眼底彩色照相、SW-AF、NIR-AF、电脑视野、光相干断层扫描(OCT)检查.结果 SW-AF、NIR-AF检查结果均显示,眼底后极部均有大小不等的强荧光环.SW-AF强荧光环内部弱荧光区域面积与NIR-AF强荧光区域面积正相关(r=0.662,P＜0.05).OCT检查证实强荧光环外的区域光感受器内外节连接(IS/OS)层和外界膜断裂、外核层变薄及色素上皮变薄萎缩.周边部视网膜骨细胞样色素沉着在SW-AF和NIR-AF中均为无荧光,眼底斑块样改变区域在SW-AF中同一位置表现为斑驳样弱荧光.SW-AF强荧光环与视野具有正相关(r=0.492,P＜0.05).结论 RP患者视野与SW-AF强荧光环内区域大小相关,且SW-AF强荧光环内区域与NIR-AF强荧光区域视网膜结构正常.
목적 관찰원발성시망막색소변성(RP)환안단파장자신형광(SW-AF)화근홍외자신형광(NIR-AF)특정이급여시야개변적상관성.방법 림상검사학진적원발성RP환자12례24지안납입연구.기중,남성9례18지안,녀성3례6지안.년령15～69세,평균년령(35.33±15.03)세.균행안저채색조상、SW-AF、NIR-AF、전뇌시야、광상간단층소묘(OCT)검사.결과 SW-AF、NIR-AF검사결과균현시,안저후겁부균유대소불등적강형광배.SW-AF강형광배내부약형광구역면적여NIR-AF강형광구역면적정상관(r=0.662,P＜0.05).OCT검사증실강형광배외적구역광감수기내외절련접(IS/OS)층화외계막단렬、외핵층변박급색소상피변박위축.주변부시망막골세포양색소침착재SW-AF화NIR-AF중균위무형광,안저반괴양개변구역재SW-AF중동일위치표현위반박양약형광.SW-AF강형광배여시야구유정상관(r=0.492,P＜0.05).결론 RP환자시야여SW-AF강형광배내구역대소상관,차SW-AF강형광배내구역여NIR-AF강형광구역시망막결구정상.
Objective To observe the characteristics of fundus autofluorescence (AF) in short wavelength AF (SW-AF) and Near Infrared AF (NIR-AF),and their relationship with visual fields.Methods Twelve patients (24 eyes) with primary RP were enrolled in this study.The patients included nine males (18 eyes) and three females (six eyes).The patients aged from 15 to 69 years,with a mean age of (35.33±15.03) years.All the patients were examined for color photography,SW-AF,NIR-AF,visual fields and optical coherence tomography examination.Results There were hyper-AF ring of varying sizes in posterior pole by SW-AF and NIR-AF examinations.The area of hypo-AF which located in SW-AF hyperAF ring had a positive correlation with the area of hyper-AF in the NIR-AF (r=0.662,P＜0.05).OCT showed that outside the hyper-AF ring,there were disconnected inner segment/outer segment (IS/OS)junction and external limiting membrane,and thinned outer nuclear layer and retinal pigment epithelium.Peripheral retinal osteocytes-like pigmentation showed non fluorescence in SW-AF and NIR-AF.The plaquelike area showed mottled and low fluorescence examined by SW-AF.SW-AF hyper-AF ring had a positive correlation with visual fields (r=0.492,P＜0.05).Conclusions The area of hypo-AF inside of the SW-AF hyper-AF ring is related to visual fields in RP patients.The retinal structures in the hypo-AF area inside of the SW-AF hyper-AF ring,and in the NIR-AF hyper-AF region are normal.