CAJ | 학술논문

目的探讨端粒酶催化亚基在膀胱内翻性乳头状瘤组织中的表达及意义。方法用RT-PCR法分别对38例膀胱内翻性乳头状瘤组织、53例膀胱低级别移行细胞癌组织、32例正常膀胱粘膜组织进行hTERT检测。结果膀胱内翻性乳头状瘤组织hTERT表达阳性23例(60.5%)，膀胱低级别移行细胞癌组织100%阳性表达；32例正常膀胱粘膜组织均无阳性表达。三者比较在统计学上具有显著性差异(P<0.01)。结论 hTERT在膀胱内翻性乳头状瘤中的高阳性表达可能与其向膀胱癌的恶性转化有关。
목적탐토단립매최화아기재방광내번성유두상류조직중적표체급의의。방법용RT-PCR법분별대38례방광내번성유두상류조직、53례방광저급별이행세포암조직、32례정상방광점막조직진행hTERT검측。결과방광내번성유두상류조직hTERT표체양성23례(60.5%)，방광저급별이행세포암조직100%양성표체；32례정상방광점막조직균무양성표체。삼자비교재통계학상구유현저성차이(P<0.01)。결론 hTERT재방광내번성유두상류중적고양성표체가능여기향방광암적악성전화유관。
Objective To evaluate the significance of detection of human telomerase reverse transcriptase (hTERT)expression in the inverted papil oma of bladder. Methods Using reverse transcriptase-polymerase chain reaction (RT-PCR) assay,hTERT in 38 inverted papil oma of bladder tissue ,53 TCC tissue and 32 normal bladder tissues were examined.Results hTERT was detected in 53 of 53 (100%)TCC tissues,23 in 38 (60.5%)the inverted papilloma of bladder and none of 32 normal bladder tissues (0),the positive rate of hTERT in TCC and in the inverted papil oma of bladder being significantly higher than than in noumal bladder tissues (PP<0.01). Conclusion The high expression of hTERT in the inverted papil oma of bladder maybe have the relelationship to its malignant transformation.