医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2014年
19期
97-98
,共2页
EB病毒Rta/IgG%VCA/IgA%鼻咽癌%诊断
EB病毒Rta/IgG%VCA/IgA%鼻嚥癌%診斷
EB병독Rta/IgG%VCA/IgA%비인암%진단
EBV Rta/IgG%VCA/IgA%Nasopharyngeal carcinoma(NPC)%Diagnosis
目的探讨EB病毒的Rta蛋白抗体IgG(Rta/IgG)在珠海地区鼻咽癌(nasopharyngeal carcinoma，NPC)患者的临床诊断价值。方法收集75例病理证实未经治疗的NPC患者血清、100例健康成人血清及肝癌、胃癌、肺癌、淋巴瘤、宫颈癌血清各19例。检测①Rta/IgG在NPC、肝癌、胃癌、肺癌、淋巴瘤、宫颈癌、健康人群的表达水平；②Rta/IgG与鼻咽癌临床分期关系；③Rta/IgG、VCA/IgA、Rta/IgG联合VCA/IgA对鼻咽癌检测率。结果①NPC患者Rta/IgG阳性率远高于健康人水平，具有显著性差异(<0.01)；并高于其他癌种的阳性率,具有显著性差异(<0.01)。②Rta/IgG的表达与NPC临床分期无统计学意义(>0.05)。③Rta/IgG、VCA/IgA及VCA/IgA联合Rta/IgG检测NPC的敏感度分别为81.3豫、89.3豫、94.6豫；特异度分别为93豫、84豫、80%。结论①Rta/IgG是NPC早期辅助诊断及筛查的可靠的血清学指标。②Rta/IgG的表达与NPC临床分期无关。③Rta/IgG联合VCA/IgA检测提高了NPC的筛检和诊断灵敏度。
目的探討EB病毒的Rta蛋白抗體IgG(Rta/IgG)在珠海地區鼻嚥癌(nasopharyngeal carcinoma，NPC)患者的臨床診斷價值。方法收集75例病理證實未經治療的NPC患者血清、100例健康成人血清及肝癌、胃癌、肺癌、淋巴瘤、宮頸癌血清各19例。檢測①Rta/IgG在NPC、肝癌、胃癌、肺癌、淋巴瘤、宮頸癌、健康人群的錶達水平；②Rta/IgG與鼻嚥癌臨床分期關繫；③Rta/IgG、VCA/IgA、Rta/IgG聯閤VCA/IgA對鼻嚥癌檢測率。結果①NPC患者Rta/IgG暘性率遠高于健康人水平，具有顯著性差異(<0.01)；併高于其他癌種的暘性率,具有顯著性差異(<0.01)。②Rta/IgG的錶達與NPC臨床分期無統計學意義(>0.05)。③Rta/IgG、VCA/IgA及VCA/IgA聯閤Rta/IgG檢測NPC的敏感度分彆為81.3豫、89.3豫、94.6豫；特異度分彆為93豫、84豫、80%。結論①Rta/IgG是NPC早期輔助診斷及篩查的可靠的血清學指標。②Rta/IgG的錶達與NPC臨床分期無關。③Rta/IgG聯閤VCA/IgA檢測提高瞭NPC的篩檢和診斷靈敏度。
목적탐토EB병독적Rta단백항체IgG(Rta/IgG)재주해지구비인암(nasopharyngeal carcinoma，NPC)환자적림상진단개치。방법수집75례병리증실미경치료적NPC환자혈청、100례건강성인혈청급간암、위암、폐암、림파류、궁경암혈청각19례。검측①Rta/IgG재NPC、간암、위암、폐암、림파류、궁경암、건강인군적표체수평；②Rta/IgG여비인암림상분기관계；③Rta/IgG、VCA/IgA、Rta/IgG연합VCA/IgA대비인암검측솔。결과①NPC환자Rta/IgG양성솔원고우건강인수평，구유현저성차이(<0.01)；병고우기타암충적양성솔,구유현저성차이(<0.01)。②Rta/IgG적표체여NPC림상분기무통계학의의(>0.05)。③Rta/IgG、VCA/IgA급VCA/IgA연합Rta/IgG검측NPC적민감도분별위81.3예、89.3예、94.6예；특이도분별위93예、84예、80%。결론①Rta/IgG시NPC조기보조진단급사사적가고적혈청학지표。②Rta/IgG적표체여NPC림상분기무관。③Rta/IgG연합VCA/IgA검측제고료NPC적사검화진단령민도。
Objective To evaluate the clinical value of Epstein-Barr virus (EBV) Rta/IgG in the diagnosis of nasopharyngeal carcinoma (NPC) patients in Zhuhai. Methods Rta/IgG and VCA/IgA was detected by enzyme-linkedimmunosorbent assay in 75 NPC patients,100 healthy adults and 60patients with dif erent tumor.Results (1)Significant dif erence of Rta/IgG positive rate between NPC group and the healthy control group ( <0.01) as well as between NPC group and other carcinoma groups( <0.01).(2)The expression levels of Rta/IgG in NPC patients serum were irrelative to the clinical stage of the tumor ( <0.05).(3)The sensitivity rates were 81.3% ,88.9%, 94.6% for Rta/IgG ,VCA/IgA , Rta/IgG or VCA/IgA respectively, while the specificity rates were 94.6%,84%,80% respectively.Conclusion Rta/IgGis a sensitive and specific serologic parameter for NPC diagnosis .but it is not a proper maker for evaluating clinical stage of NPC.The combined detection of Rta/IgG and VCA/IgA has referential value in diagnosing nasopharyngeal carcinoma patients in Zhuhai.
