中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2014年
20期
20-23
,共4页
急性脑梗死%非快速眼球运动期%睡眠障碍%认知功能
急性腦梗死%非快速眼毬運動期%睡眠障礙%認知功能
급성뇌경사%비쾌속안구운동기%수면장애%인지공능
Acute cerebral infarction%Non-rapid eye movement%Sleep disorder%Cognitive function
目的：探讨急性脑梗死患者非快速眼球运动期(NREM)睡眠障碍与认知功能的关系。方法利用蒙特利尔认知评估量表(MoCA)、简易智能状态量表(MMSE)、多导睡眠图对河北北方学院附属第一医院56例急性脑梗死伴NREM睡眠障碍患者(病例组)和同期32例急性脑梗死患者(对照组)的认知功能进行评估和比较。结果病例组NREM睡眠S1期[(155.58±47.94)min]长于对照组[(110.00±38.76)min]，NREM睡眠S2期[(80.75±33.05)min]、S3+S4期[(15.01±12.79)min]均短于对照组[(120.02±28.08)、(66.32±18.92) min]，差异均有高度统计学意义(P<0.01)。对照组MoCA中视空间与执行总分[(4.61±0.43)分]，命名总分[(3.00±0.01)分]均高于病例组[(2.36±0.98)、(2.38±0.61)分]，差异均有统计学意义(P<0.05或P<0.01)。病例组时间定向[(2.76±1.51)分]、注意计算[(2.50±1.96)分]、延迟记忆[(1.50±0.62)分]、结构能力[(0.51±0.43)分]得分低于对照组[(4.76±0.38)、(2.62±0.42)、(2.65±0.42)、(1.00±0.00)分]，差异有统计学意义(P<0.05或P<0.01)。结论急性脑梗死患者NREM睡眠S2期、S3+S4期时间缩短，认知功能下降，睡眠结构变化与认知功能可能存在相关性。
目的：探討急性腦梗死患者非快速眼毬運動期(NREM)睡眠障礙與認知功能的關繫。方法利用矇特利爾認知評估量錶(MoCA)、簡易智能狀態量錶(MMSE)、多導睡眠圖對河北北方學院附屬第一醫院56例急性腦梗死伴NREM睡眠障礙患者(病例組)和同期32例急性腦梗死患者(對照組)的認知功能進行評估和比較。結果病例組NREM睡眠S1期[(155.58±47.94)min]長于對照組[(110.00±38.76)min]，NREM睡眠S2期[(80.75±33.05)min]、S3+S4期[(15.01±12.79)min]均短于對照組[(120.02±28.08)、(66.32±18.92) min]，差異均有高度統計學意義(P<0.01)。對照組MoCA中視空間與執行總分[(4.61±0.43)分]，命名總分[(3.00±0.01)分]均高于病例組[(2.36±0.98)、(2.38±0.61)分]，差異均有統計學意義(P<0.05或P<0.01)。病例組時間定嚮[(2.76±1.51)分]、註意計算[(2.50±1.96)分]、延遲記憶[(1.50±0.62)分]、結構能力[(0.51±0.43)分]得分低于對照組[(4.76±0.38)、(2.62±0.42)、(2.65±0.42)、(1.00±0.00)分]，差異有統計學意義(P<0.05或P<0.01)。結論急性腦梗死患者NREM睡眠S2期、S3+S4期時間縮短，認知功能下降，睡眠結構變化與認知功能可能存在相關性。
목적：탐토급성뇌경사환자비쾌속안구운동기(NREM)수면장애여인지공능적관계。방법이용몽특리이인지평고량표(MoCA)、간역지능상태량표(MMSE)、다도수면도대하북북방학원부속제일의원56례급성뇌경사반NREM수면장애환자(병례조)화동기32례급성뇌경사환자(대조조)적인지공능진행평고화비교。결과병례조NREM수면S1기[(155.58±47.94)min]장우대조조[(110.00±38.76)min]，NREM수면S2기[(80.75±33.05)min]、S3+S4기[(15.01±12.79)min]균단우대조조[(120.02±28.08)、(66.32±18.92) min]，차이균유고도통계학의의(P<0.01)。대조조MoCA중시공간여집행총분[(4.61±0.43)분]，명명총분[(3.00±0.01)분]균고우병례조[(2.36±0.98)、(2.38±0.61)분]，차이균유통계학의의(P<0.05혹P<0.01)。병례조시간정향[(2.76±1.51)분]、주의계산[(2.50±1.96)분]、연지기억[(1.50±0.62)분]、결구능력[(0.51±0.43)분]득분저우대조조[(4.76±0.38)、(2.62±0.42)、(2.65±0.42)、(1.00±0.00)분]，차이유통계학의의(P<0.05혹P<0.01)。결론급성뇌경사환자NREM수면S2기、S3+S4기시간축단，인지공능하강，수면결구변화여인지공능가능존재상관성。
Objective To study the correlation between non-rapid eye movement (NREM) sleep disorder and cognitive function in patients with acute cerebral infarction. Methods Cognitive function of 56 cases of patients with acute cere-bral infarction and NREM sleep disorders (case group) in the First Hospital Affiliated to Hebei North University and 32 cases of patients with acute cerebral infarction in the same period (control group) were assessed and compared by the Montreal cognitive assessment scale (MoCA), simple intelligent state scale (MMSE), and polysomnogram. Results The stage S1 of NREM sleep in case group [(155.58±47.94) min] was longer than that of control group [(110.00±38.76) min], stage S2 of NREM sleep [(80.75±33.05) min], stage S3+S4 [(15.01±12.79) min] were shorter than those of control group [(120.02±28.08), (66.32±18.92) min], the differences were statistically significant (P< 0.01). The MoCA scores in visu-ospatial and executive of control group [(4.61±0.43) points], naming score [(3.00±0.01) points] were higher than those of case group [(2.36±0.98), (2.38±0.61) points], the differences were statistically significant (P< 0.05). Scores of time ori-entation [(2.76±1.51) points], attention of calculation [(2.50±1.96) points], delayed memory [(1.50±0.62) points], struc-tural capabilities [(0.51±0.43) points] of case group were lower than those of control group [(4.76±0.38), (2.62±0.42), (2.65±0.42), (1.00±0.00) points], the differences were statistically significant (P<0.05 or P<0.01). Conclusion The patients with acute cerebral infarction have shorter NREM sleep time in stage S2 and S3+S4 and cognitive decline, there may be a correlation between sleep structure changes and cognitive function.
