医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2014年
20期
66-67
,共2页
骨折手术部位感染%超敏c-反应蛋白%白细胞介素-18%β-防御素-3
骨摺手術部位感染%超敏c-反應蛋白%白細胞介素-18%β-防禦素-3
골절수술부위감염%초민c-반응단백%백세포개소-18%β-방어소-3
bone fracture operative site infection%high sensitive C-reactive protein(hs-CRP)%interleukin-18(IL-18)%beta-defeusin-3
目的:探讨了骨折手术部位感染患者治疗前后血清hs-CRP,IL-18和血浆β-防御素-3水平的变化,分析其与骨折手术部位感染的危险性相关性。方法:应用免疫比浊法,酶联法对20例骨折手术部位感染患者进行了治疗前后血清h s-C R P,I L-18和血浆β-防御素-3进行了水平检测,并与65名非感染患者和35名正常健康人作比较。结果:骨折手术部位感染患者在治疗前血清hs-CRP,IL-18水平非常显著地高于正常人组和手术部位无感染患者(p<0.01),而血浆β-防御素-3水平又非常显著地低于正常人组(p<0.01),经综合治疗3个月后则与正常人比较无显著性差异(p>0.05),血浆β-防御素-3水平与血清hs-CRP,IL-18水平呈显著负相关(r=-0.6011,-0.6721,p<0.01)。结论:骨折手术部位感染患者血清hs-CRP,IL-18水平的升高和血浆β-防御素-3水平的降低,可能是骨折手术部位感染的危险因素。
目的:探討瞭骨摺手術部位感染患者治療前後血清hs-CRP,IL-18和血漿β-防禦素-3水平的變化,分析其與骨摺手術部位感染的危險性相關性。方法:應用免疫比濁法,酶聯法對20例骨摺手術部位感染患者進行瞭治療前後血清h s-C R P,I L-18和血漿β-防禦素-3進行瞭水平檢測,併與65名非感染患者和35名正常健康人作比較。結果:骨摺手術部位感染患者在治療前血清hs-CRP,IL-18水平非常顯著地高于正常人組和手術部位無感染患者(p<0.01),而血漿β-防禦素-3水平又非常顯著地低于正常人組(p<0.01),經綜閤治療3箇月後則與正常人比較無顯著性差異(p>0.05),血漿β-防禦素-3水平與血清hs-CRP,IL-18水平呈顯著負相關(r=-0.6011,-0.6721,p<0.01)。結論:骨摺手術部位感染患者血清hs-CRP,IL-18水平的升高和血漿β-防禦素-3水平的降低,可能是骨摺手術部位感染的危險因素。
목적:탐토료골절수술부위감염환자치료전후혈청hs-CRP,IL-18화혈장β-방어소-3수평적변화,분석기여골절수술부위감염적위험성상관성。방법:응용면역비탁법,매련법대20례골절수술부위감염환자진행료치료전후혈청h s-C R P,I L-18화혈장β-방어소-3진행료수평검측,병여65명비감염환자화35명정상건강인작비교。결과:골절수술부위감염환자재치료전혈청hs-CRP,IL-18수평비상현저지고우정상인조화수술부위무감염환자(p<0.01),이혈장β-방어소-3수평우비상현저지저우정상인조(p<0.01),경종합치료3개월후칙여정상인비교무현저성차이(p>0.05),혈장β-방어소-3수평여혈청hs-CRP,IL-18수평정현저부상관(r=-0.6011,-0.6721,p<0.01)。결론:골절수술부위감염환자혈청hs-CRP,IL-18수평적승고화혈장β-방어소-3수평적강저,가능시골절수술부위감염적위험인소。
objective:To explore the Serum hs-CRP,IL-18 and plasma Beta-Defeusin-3 concentration after treatment in patients with bone fracture operative site infections and its clinical assesement .Analysis its correlation with diseases was evaluated. Methods:serum hs-CRP(with inmuno turbility method)serum IL-18 and plasma Beta-defension-3(with ELISA)levels were determined in 20 cases with bone fracture operative site infections and 65 cases without 35 controls. Results:before treatment,serum hs-CRP,IL-18 levels were significantly higher than those in controls (p<0.01),but Beta-defension-3 levels were significantly lower (p<0.01),after treatment for 3 mouths ,the levels were not significantly different from those in controls (p>0.05) plasma Beta-defension-3 levels were negatively correlated with serum hs-CRP,IL-18 levels (r=-0.6011,-0.6721, p<0.01)conclusions:increases of hs-CRP,IL-18 and decreased Beta-defen-3 is found after bone fracture operative site infections maybe independently associated with bone fracture operative site infection.