医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2014年
20期
48-49
,共2页
类风湿关节炎%Th17细胞%IL-17%IL-6%IL-23
類風濕關節炎%Th17細胞%IL-17%IL-6%IL-23
류풍습관절염%Th17세포%IL-17%IL-6%IL-23
rheumatoid arthritis%Th17 cels%IL-17%IL-6%IL-23
目的：探讨 Th17细胞相关细胞因子IL-17、IL-6、IL-23在类风湿关节炎（rheumatoid arthritis，RA）发病机制中的作用。方法用酶联免疫吸附法检测35例活动组RA患者、35例缓解组 RA 患者及30例健康人血清 IL-17、IL-6、IL-23的水平，并分析它们与活动度和实验室指标的关系。结果RA活动组和缓解组血清IL-23、IL-6水平均明显高于对照组（p<0.05），而RA活动组与缓解租相比，差异亦有统计学意义（p<0.05）。RA 活动组与缓解组血清IL-17水平均高于对照组（p<0.05），但 RA 缓解组与对照组比较差异无统计学意义（p>0.05）。RA患者血清IL-17、IL-6和IL-23水平分别与DAS28评分、CRP、ESR， DAS28评分、RF、CRP、ESR和DAS28评分、ESR相关(p＜0.05)。RA患者血清IL-17、IL-6和IL-23水平之间互为正相关关系。结论 Th17细胞相关细胞因子IL-17、IL-6、IL-23均在RA 的发生、发展过程中起着重要作用，并可作为RA活动参考指标。
目的：探討 Th17細胞相關細胞因子IL-17、IL-6、IL-23在類風濕關節炎（rheumatoid arthritis，RA）髮病機製中的作用。方法用酶聯免疫吸附法檢測35例活動組RA患者、35例緩解組 RA 患者及30例健康人血清 IL-17、IL-6、IL-23的水平，併分析它們與活動度和實驗室指標的關繫。結果RA活動組和緩解組血清IL-23、IL-6水平均明顯高于對照組（p<0.05），而RA活動組與緩解租相比，差異亦有統計學意義（p<0.05）。RA 活動組與緩解組血清IL-17水平均高于對照組（p<0.05），但 RA 緩解組與對照組比較差異無統計學意義（p>0.05）。RA患者血清IL-17、IL-6和IL-23水平分彆與DAS28評分、CRP、ESR， DAS28評分、RF、CRP、ESR和DAS28評分、ESR相關(p＜0.05)。RA患者血清IL-17、IL-6和IL-23水平之間互為正相關關繫。結論 Th17細胞相關細胞因子IL-17、IL-6、IL-23均在RA 的髮生、髮展過程中起著重要作用，併可作為RA活動參攷指標。
목적：탐토 Th17세포상관세포인자IL-17、IL-6、IL-23재류풍습관절염（rheumatoid arthritis，RA）발병궤제중적작용。방법용매련면역흡부법검측35례활동조RA환자、35례완해조 RA 환자급30례건강인혈청 IL-17、IL-6、IL-23적수평，병분석타문여활동도화실험실지표적관계。결과RA활동조화완해조혈청IL-23、IL-6수평균명현고우대조조（p<0.05），이RA활동조여완해조상비，차이역유통계학의의（p<0.05）。RA 활동조여완해조혈청IL-17수평균고우대조조（p<0.05），단 RA 완해조여대조조비교차이무통계학의의（p>0.05）。RA환자혈청IL-17、IL-6화IL-23수평분별여DAS28평분、CRP、ESR， DAS28평분、RF、CRP、ESR화DAS28평분、ESR상관(p＜0.05)。RA환자혈청IL-17、IL-6화IL-23수평지간호위정상관관계。결론 Th17세포상관세포인자IL-17、IL-6、IL-23균재RA 적발생、발전과정중기착중요작용，병가작위RA활동삼고지표。
Objective To investigate clinical significances of Th17 related cytokines IL-17, IL-6 and IL-23 in patients with RA. Methods The patients were divided into different groups according to the RA disease activity score (DAS28),35 patients with active RA and 35 patients with inactive RA .Thirty healthy volunteers were recruited as the normal control. Concentrations of serum IL-17, IL-6 and IL-23 were measured by Enzyme linked immunosorbent assay (ELISA).The relationship between Th17 related cytokines and laboratory data were analyzed at the same time. Results Compared with the normal control, the levels of serum IL-23 and IL-6 in patients with RA were significantly increased(p<0.05), and there showed the satatistic differences between patients with active RA and inactive RA(p<0.05). Compared with normal controls, the levels of serum IL-17 in patients with RA were significantly increased, and there showed no statistic differences between patients with inactive RA and normal controls.The levels of serum IL-17, IL-6 and IL-23 were positively correlated with DAS28 Score、CRP、ESR,DAS28 Score、RF、CRP、ESR and DAS28 Score、ESR respectively(p<0.05). Conclusion The results suggest that Th17 related cytokines IL-17, IL-6 and IL-23 may play important roles in the pathogenesis of RA and can be indicators of disease activity.
