CAJ | 학술논문

低氧是肿瘤发生侵袭转移必经的过程之一，它促进了肿瘤致癌基因的表达，从而使肿瘤细胞发生远处转移。低氧环境对于调节肿瘤的EMT过程具有重要作用，刺激肿瘤的恶化和转移，也可促进血管激活因子的表达从而促进肿瘤血管的形成。 CCNE2作为调节细胞周期的关键基因，在肿瘤发生和转移过程中的作用已经得到广泛研究，在多种癌细胞中都发现 CCNE2蛋白是高表达的。为此在 MCF-7细胞中通过一系列的实验证明了CCNE2是一个新的低氧靶基因，并证明了低氧通过刺激HIF-2α促进了CCNE2的表达。
저양시종류발생침습전이필경적과정지일，타촉진료종류치암기인적표체，종이사종류세포발생원처전이。저양배경대우조절종류적EMT과정구유중요작용，자격종류적악화화전이，야가촉진혈관격활인자적표체종이촉진종류혈관적형성。 CCNE2작위조절세포주기적관건기인，재종류발생화전이과정중적작용이경득도엄범연구，재다충암세포중도발현 CCNE2단백시고표체적。위차재 MCF-7세포중통과일계렬적실험증명료CCNE2시일개신적저양파기인，병증명료저양통과자격HIF-2α촉진료CCNE2적표체。
Hypoxia is one of the process of tumorigenesis and tumor metastasis,it promotes the expression of tumors which promotes tumor cells distant metastasis. Hypoxia plays an important role in EMT process, which stimulates the degradation and metastasis of tumor,moreover,it promotes the expression of vascular activator to induce the formation of tumor blood vessels. As a key regulating in cell cycle genes,the role of CCNE2 in tumorigenesis and metastasis has been extensively studied,CCNE2 is found to express more than normal cells in various cancer cells. For these,a series of ex-periments are done to demonstrate CCNE2 is a new target to hypoxia and hypoxia induces the expression of CCNE2 by HIF-2α.