CAJ | 학술논문

目的：在慢性强迫游泳应激模型上，观察电针对大鼠行为及血清五羟色胺（5-HT）含量的影响。方法：将雄性SD大鼠随机分为正常对照组、模型组、电针组和氟西汀组，每组10只。采用慢性强迫游泳应激方法制备抑郁大鼠模型。通过体质量、旷场实验、糖水实验对大鼠进行行为学评价，用ELISA方法检测大鼠血清中的5-HT含量。结果：与正常组比较，模型组大鼠体质量、旷场实验的水平运动和垂直运动次数、糖水摄入量均明显下降（P＜0．05），血清5-HT含量降低（P＜0．05）。与模型组比较，电针组和氟西汀组大鼠体质量、旷场实验中的平行活动和垂直运动次数、糖水摄入量均明显增加（P＜0.05），血清中的5-HT含量明显增加（P＜0．05），电针组与氟西汀组之间比较，无显著性差异（ P＞0.05）。结论：电针可改善慢性强迫游泳应激导致的大鼠抑郁样行为异常，明显增加血清中5-HT含量，具有抗抑郁作用。
목적：재만성강박유영응격모형상，관찰전침대대서행위급혈청오간색알（5-HT）함량적영향。방법：장웅성SD대서수궤분위정상대조조、모형조、전침조화불서정조，매조10지。채용만성강박유영응격방법제비억욱대서모형。통과체질량、광장실험、당수실험대대서진행행위학평개，용ELISA방법검측대서혈청중적5-HT함량。결과：여정상조비교，모형조대서체질량、광장실험적수평운동화수직운동차수、당수섭입량균명현하강（P＜0．05），혈청5-HT함량강저（P＜0．05）。여모형조비교，전침조화불서정조대서체질량、광장실험중적평행활동화수직운동차수、당수섭입량균명현증가（P＜0.05），혈청중적5-HT함량명현증가（P＜0．05），전침조여불서정조지간비교，무현저성차이（ P＞0.05）。결론：전침가개선만성강박유영응격도치적대서억욱양행위이상，명현증가혈청중5-HT함량，구유항억욱작용。
Objective:To observe the effects of electroacupuncture ( EA) on depressive-like behavior and ser-um 5-hydroxytryptamine (5-HT) of the chronic forced swim stress model rats .Methods:40 male SD rats were evenly randomized into normal control , model, fluoxetine and EA groups .The chronic stress rat model was established by chronic forced swim .The behaviors were evaluated by body weight , open field test and su-crose intake test , the serum 5-HT was detected by ELISA .Results: Compared with the control group , the body weight , crossings and rearings in the open field test , the sucrose intake , and the serum 5-HT of model group were decreased significantly (P<0.05).Compared with the model group , the body weight, crossings and rearings in the open field test , the sucrose intake , and the serum 5-HT of fluoxetine group and EA group were all increased significantly (P<0.05).But there was no significant difference between EA group and flu-oxetine group (P>0.05).Conclusion:Electroacupuncture can improve the model rats ’ depressive-like be-haviors which are caused by chronic forced swim stress , and may increase the serum 5-HT of the model rats . Hereby , electroacupuncture may have anti -depressive effects .