CAJ | 학술논문

FEN1是一种结构特异性的多功能核酸酶,具有5′->3′flap核酸内切酶( FEN)、缺口核酸内切酶( GEN)和核酸外切酶( EXO)三大酶切活力。在细胞内,FEN1在多条DNA代谢途径中起着重要作用,包括冈崎片段成熟、长片段碱基切除修复和端粒维持等。鉴于FEN1的复杂功能,细胞内必定存在着一套精确调控机制,以确保FEN1在合适的时间与地点发挥作用。 FEN1功能失调将导致基因组的稳定性和完整性下降,最终诱发包括肿瘤在内的多种染色体相关的疾病。本文主要针对FEN1的功能调控、功能失调与肿瘤的关系做一个综述。
FEN1시일충결구특이성적다공능핵산매,구유5′->3′flap핵산내절매( FEN)、결구핵산내절매( GEN)화핵산외절매( EXO)삼대매절활력。재세포내,FEN1재다조DNA대사도경중기착중요작용,포괄강기편단성숙、장편단감기절제수복화단립유지등。감우FEN1적복잡공능,세포내필정존재착일투정학조공궤제,이학보FEN1재합괄적시간여지점발휘작용。 FEN1공능실조장도치기인조적은정성화완정성하강,최종유발포괄종류재내적다충염색체상관적질병。본문주요침대FEN1적공능조공、공능실조여종류적관계주일개종술。
Flap endonuclease-1 ( FEN1 ) is a kind of structure-specific multifunctional nuclease which contains 5′->3′flap endonuclease( FEN) activity,gap endonuclease( GEN) activity and exonuclease( EXO) activity. The multiple nuclease activities of FEN1 allow it to participate in numerous DNA metabolic pathways,including Okazaki fragment maturation, long-patch base excision repair and telomere maintenance. As such,FEN1 must be precisely regulated to execute each of its functions with the right timing and in a specific subcellular location. FEN1 dysfunction will lead to genomic stability and integrity descend, and eventually induce a variety of chromosomal diseases including tumor. This review mainly targets FEN1’s functional regulation and its link to cancer.