CAJ | 학술논문

目的：探讨转化生长因子-β1（ TGF-β1）基因多态性与中国人群HBV感染敏感性的关系。方法：本研究为以中国人群为研究对象的病例-对照研究，随机纳入50例HBV感染者（观察组）和50例与病例组性别、年龄相匹配的健康者（对照组）。采用聚合酶链反应-限制性片段长度多态性分析法检测TGF-β1基因T29 C多态性。结果：病例组和对照组基因型和等位基因分布均有明显差异（χ2＝12.795， df＝2， P＝0.002；χ2＝10.895， df ＝1， P＝0.002）。携带基因型TC和CC感染HBV的风险显著升高（ OR＝4.227，95％CI：1.604～11.139， P＝0.004； OR＝8.250，95％CI：2.042～33.334， P＝0.003）。携带等位基因C较等位基因T感染HBV的风险显著升高（ OR＝2.631，95％CI：1.472～4.702， P＝0.001）。结论： TGF-β1基因T29C多态性可能与HBV感染风险有关。
목적：탐토전화생장인자-β1（ TGF-β1）기인다태성여중국인군HBV감염민감성적관계。방법：본연구위이중국인군위연구대상적병례-대조연구，수궤납입50례HBV감염자（관찰조）화50례여병례조성별、년령상필배적건강자（대조조）。채용취합매련반응-한제성편단장도다태성분석법검측TGF-β1기인T29 C다태성。결과：병례조화대조조기인형화등위기인분포균유명현차이（χ2＝12.795， df＝2， P＝0.002；χ2＝10.895， df ＝1， P＝0.002）。휴대기인형TC화CC감염HBV적풍험현저승고（ OR＝4.227，95％CI：1.604～11.139， P＝0.004； OR＝8.250，95％CI：2.042～33.334， P＝0.003）。휴대등위기인C교등위기인T감염HBV적풍험현저승고（ OR＝2.631，95％CI：1.472～4.702， P＝0.001）。결론： TGF-β1기인T29C다태성가능여HBV감염풍험유관。
Objective: To investigate the relationship between polymorphism at transforming growth factor -β1 ( TGF-β1 ) gene and the risk of hepatitis B virus ( HBV) infection in Chinese population.Methods: This study was a case-control study , fifty patients with hepatitis B virus infection and 50 age-and sex-matched healthy individuals were randomly enrolled to our stu-dy.Polymerase chain reaction-restriction fragment length polymorphism technique was used to detect single nucleotide polymor -phism of TGF-β1 T29C.Results: There were significant differences in the genotypic distribution and allele frequency of TGF -β1 polymorphism T29C (χ2 =12.795, df=2, P=0.002;χ2 =10.895, df=1, P=0.002) .There was significantly increased risk in HBV infection patients with TC and CC genotype ( OR=4.227, 95%CI:1.604 ~11.139, P=0.004; OR=8.250, 95%CI:2.042~33.334, P=0.003), risk of HBV infection on patients with allele C compared was higher than those with al-lele T (OR=2.631, 95%CI:1.472~4.702, P=0.001) .Conclusion: TGF-β1 gene polymorphism (T29C) may be related to the risk of HBV infection.