CAJ | 학술논문

目的：探讨慢性HBV感染者病原学特点与治疗及转归的相关性。方法：根据慢性HBV感染者的病原学特点及有无肝损害情况，将282例慢性HBV感染者分为6组，观察其各项实验室指标的情况。结果： A2型患者HBeAg阴转例数多于A1型患者（ P＜0.05）； A2型患者HBeAg阴转的治疗时间较短于A1型患者（ P＜0.01）； C型患者病毒复制指标反弹的例数多于A型患者（P＜0.05）； C型患者伴有肝硬化的例数多于A型患者（P＜0.01）； C型有肝硬化患者HBV DNA反弹例数多于无肝硬化患者（ P＜0.05）； C型有肝硬化患者HBV DNA清除时间较长于无肝硬化患者（P＜0.05）。结论：双抗原阳性有肝损害的患者HBeAg阴转率较高，治疗时间较短；单抗原HBsAg阳性且HBV DNA阳性感染者较易发展为肝硬化，此型患者病毒清除时间较长且易反弹。因此，对于单抗原HBsAg阳性且HBV DNA阳性感染者，提倡早期治疗，否则进展为肝硬化时，治疗难度增加，病情易反复。
목적：탐토만성HBV감염자병원학특점여치료급전귀적상관성。방법：근거만성HBV감염자적병원학특점급유무간손해정황，장282례만성HBV감염자분위6조，관찰기각항실험실지표적정황。결과： A2형환자HBeAg음전례수다우A1형환자（ P＜0.05）； A2형환자HBeAg음전적치료시간교단우A1형환자（ P＜0.01）； C형환자병독복제지표반탄적례수다우A형환자（P＜0.05）； C형환자반유간경화적례수다우A형환자（P＜0.01）； C형유간경화환자HBV DNA반탄례수다우무간경화환자（ P＜0.05）； C형유간경화환자HBV DNA청제시간교장우무간경화환자（P＜0.05）。결론：쌍항원양성유간손해적환자HBeAg음전솔교고，치료시간교단；단항원HBsAg양성차HBV DNA양성감염자교역발전위간경화，차형환자병독청제시간교장차역반탄。인차，대우단항원HBsAg양성차HBV DNA양성감염자，제창조기치료，부칙진전위간경화시，치료난도증가，병정역반복。
Objective: To explore the correlation among etiology character of TCM chronic HBV infection and treatment , disease prognosis.Methods: According to the etiology character of chronic HBV infection and the presence of hepatic injury , the 282 cases of chronic HBV infection were divided into six groups and observed their laboratory indexes .Results: The cases of A2 group with HBeAg transferring negative were more than the groups A 1 ( P<0.05 ); the therapy course of A 2 group with transferring negative was shorter in the group A1 (P<0.01);comparison of C-type and A-type, the former prone to the rebound of viral replication index (P<0.05);the number of C-type patients with cirrhosis was more than the A-type (P<0.01); the number of C-type patients with cirrhosis was more than the C-type non-cirrhotic patients ( P<0.05); the therapy course of C-type patients with cirrhosis was longer than the C-type non-cirrhotic patients ( P<0.05 ) .Conclusion: The HBeAg negative rate of double-antigen positive patients with hepatic injury is higher and the therapy course is shorter ;single antigen HBsAg posi-tive and HBV DNA positive patients are likely to develop into liver cirrhosis;this type of patients with viral clearance time is long and easy to rebound.Therefore, for a single antigen HBsAg positive and HBV DNA positive infection , promote early treatment, otherwise the progress to cirrhosis , treatment more difficult , illness capricious.