CAJ | 학술논문

目的：探讨放疗联合TP方案化疗对晚期食管癌治疗效果。方法：将58例经病理学确诊的中晚期食道癌患者随机分组，联合治疗组应用放疗加化疗（n=29），化疗后休息1周，采用6MV X射线常规分割，前后对穿和等中心斜野照射。单纯放射治疗组(n=29)放疗方法同联合组。结果：①近期疗效：联合组近期有效率为92.6%，单放组为71.4%(P<0.05)。②生存率：联合组1、2、3年生存率分别为67%、52%和41%，较单放组显著提高（P<0.05）。③症状改善情况：联合组治疗结束能进普食或软食者为79.5%，放疗组为63.1%，两组差异有统计学意义(P<0.05)。④不良反应：综合组略高于单放组，但能耐受。结论：放射治疗加TP化疗联合组疗效优单纯放疗，值得临床推广。
목적：탐토방료연합TP방안화료대만기식관암치료효과。방법：장58례경병이학학진적중만기식도암환자수궤분조，연합치료조응용방료가화료（n=29），화료후휴식1주，채용6MV X사선상규분할，전후대천화등중심사야조사。단순방사치료조(n=29)방료방법동연합조。결과：①근기료효：연합조근기유효솔위92.6%，단방조위71.4%(P<0.05)。②생존솔：연합조1、2、3년생존솔분별위67%、52%화41%，교단방조현저제고（P<0.05）。③증상개선정황：연합조치료결속능진보식혹연식자위79.5%，방료조위63.1%，량조차이유통계학의의(P<0.05)。④불량반응：종합조략고우단방조，단능내수。결론：방사치료가TP화료연합조료효우단순방료，치득림상추엄。
Objective:To evaluate the feasibility and efficacy of radiation therapy combined with TP chemotherapy for esophageal cancer.Methods:Total of 58 advanced esophageal carcinoma patients were randomized into two groups.29 patients in combined group received chemo-radiotherapy(Combined Group).The other group (n=29) was only given radiotherapy (Radiotherapy Group). Results:The short term efficacy, survival rate and clinical improvement in the combined group were higher than that in radiotherapy group ( P<0.05).Though the acute toxic effect was server in combined group than in radiotherapy only group ( P<0.05),it was controllable. Conclusion:The result of radiotherapy combined TP chemotherapy was more effective than radiotherapy alone in the treatment of esophageal cancer.