安徽卫生职业技术学院学报
安徽衛生職業技術學院學報
안휘위생직업기술학원학보
JOURNAL OF ANHUI HEALTH VOCATIONAL & TECHNICAL COLLEGE
2014年
3期
29-30
,共2页
新生儿%ABO溶血病%丙种球蛋白%疗效
新生兒%ABO溶血病%丙種毬蛋白%療效
신생인%ABO용혈병%병충구단백%료효
Newborn%ABO-hemolytic disease%Gamma Globulin%Curative Effect
目的：观察大剂量静脉输注丙种球蛋白(IVIG)治疗新生儿ABO溶血病的疗效。方法：对63例ABO溶血病患儿随机分为治疗组(35例)和对照组(28例)，治疗组给予常规治疗+大剂量IVIG治疗，对照组仅给予常规治疗，分别监测血清总胆红素和血红蛋白，记录两组患儿的光疗时间及黄疸消退时间。结果：治疗组的血清总胆红素显著低于对照组[(112.50±50.43)ummol/L VS（202.50±60.51）ummol/L,P<0.05]，光疗时间[（29.25±15.43）h VS（41.46±17.54）h, P<0.05]及黄疸消退时间[(4.52±1.41)h VS (6.15±1.67）h,P<0.05)]较对照组明显缩短，差异均有统计学意义。两组间血红蛋白无明显差异，但对照组的血红蛋白较治疗组有下降趋势。结论：应用丙种球蛋白治疗新生儿ABO溶血病，可有效降低血清总胆红素，缩短患儿的光疗时间及黄疸消退时间。
目的：觀察大劑量靜脈輸註丙種毬蛋白(IVIG)治療新生兒ABO溶血病的療效。方法：對63例ABO溶血病患兒隨機分為治療組(35例)和對照組(28例)，治療組給予常規治療+大劑量IVIG治療，對照組僅給予常規治療，分彆鑑測血清總膽紅素和血紅蛋白，記錄兩組患兒的光療時間及黃疸消退時間。結果：治療組的血清總膽紅素顯著低于對照組[(112.50±50.43)ummol/L VS（202.50±60.51）ummol/L,P<0.05]，光療時間[（29.25±15.43）h VS（41.46±17.54）h, P<0.05]及黃疸消退時間[(4.52±1.41)h VS (6.15±1.67）h,P<0.05)]較對照組明顯縮短，差異均有統計學意義。兩組間血紅蛋白無明顯差異，但對照組的血紅蛋白較治療組有下降趨勢。結論：應用丙種毬蛋白治療新生兒ABO溶血病，可有效降低血清總膽紅素，縮短患兒的光療時間及黃疸消退時間。
목적：관찰대제량정맥수주병충구단백(IVIG)치료신생인ABO용혈병적료효。방법：대63례ABO용혈병환인수궤분위치료조(35례)화대조조(28례)，치료조급여상규치료+대제량IVIG치료，대조조부급여상규치료，분별감측혈청총담홍소화혈홍단백，기록량조환인적광료시간급황달소퇴시간。결과：치료조적혈청총담홍소현저저우대조조[(112.50±50.43)ummol/L VS（202.50±60.51）ummol/L,P<0.05]，광료시간[（29.25±15.43）h VS（41.46±17.54）h, P<0.05]급황달소퇴시간[(4.52±1.41)h VS (6.15±1.67）h,P<0.05)]교대조조명현축단，차이균유통계학의의。량조간혈홍단백무명현차이，단대조조적혈홍단백교치료조유하강추세。결론：응용병충구단백치료신생인ABO용혈병，가유효강저혈청총담홍소，축단환인적광료시간급황달소퇴시간。
Objective:To observe the curative effect of large-dose intravenous immunoglobulin(IVIG) in treatment of neonatal ABO-hemolysis.Methods:63 cases of ABO-hemolysis were randomly divided into 2 groups,35 cases in treatment group and 28 cases in the contral group. The treatment groupWas given both routine therapy and large-dose IVIG, while the control group was given only routine therap,monitoring the serum total bilirubin and hemoglobin, recording the phototherapy time and jaundice regression time. Results:The total serum bilirubin of treatment group was significantly lower than control group (112.50±50.43 ummol/L VS 202.50±60.51 ummol/L,P<0.05).The photother-apy time(29.25±15.43 h VS 41.46±17.54 h, P<0.05) and jaundice regression time(4.52±1.41 h VS 6.15±1.67 h, P<0.05) of treatment group were significantly shorter than those of control group.The hemoglobin of 2 groups have no significant differences, but the hemoglobin of contral group have a downward trend when compared with the treatment group.Conclusion:Gamma globulin is effective for neonatal ABO-hemolysis in reducing the level of total serum bilirubin,the duration of phototherapy and the regression time of jaundice.
