CAJ | 학술논문

目的：探讨氨磺必利与舒必利治疗精神分裂症的临床疗效和安全性。方法将100例精神分裂症患者随机分为两组，每组50例，研究组口服氨磺必利治疗，对照组口服舒必利治疗，观察8周。采用阳性与阴性症状量表评定临床疗效，副反应量表评定不良反应。结果治疗8周末研究组总有效率90．0％，对照组为84．0％，两组总有效率比较差异无显著性（χ2＝0．80， P＞0．05）；研究组不良反应发生率为16．0％，对照组为52．0％，研究组不良反应发生率显著低于对照组（χ2＝14．44，P＜0．01）。结论氨磺必利与舒必利治疗精神分裂症疗效显著，总体疗效相当，但氨磺必利治疗不良反应轻微，安全性高，依从性好。
목적：탐토안광필리여서필리치료정신분렬증적림상료효화안전성。방법장100례정신분렬증환자수궤분위량조，매조50례，연구조구복안광필리치료，대조조구복서필리치료，관찰8주。채용양성여음성증상량표평정림상료효，부반응량표평정불량반응。결과치료8주말연구조총유효솔90．0％，대조조위84．0％，량조총유효솔비교차이무현저성（χ2＝0．80， P＞0．05）；연구조불량반응발생솔위16．0％，대조조위52．0％，연구조불량반응발생솔현저저우대조조（χ2＝14．44，P＜0．01）。결론안광필리여서필리치료정신분렬증료효현저，총체료효상당，단안광필리치료불량반응경미，안전성고，의종성호。
Objective To explore the efficacy and safety of amisulpride and sulpiride in the treatment of schizophrenia .Methods A total of 100 schizophrenia patients were randomly divided into two groups of 50 ones each ,research group took orally amisulpride and control group did sulpiride for 8 weeks .Clinical effi-cacies were assessed with the Positive and Negative Syndrome Scale (PANSS) and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results Total effective rate was respectively 90 .0% in research and 84 .0% in control group at the end of the 8th week ,which showed no significant group differ-ence (χ2 =0 .80 , P> 0 .05);the incidence of adverse reaction was respectively 16 .0% in research and 52 .0% in control group ,the former was significantly lower than the latter (χ2 =14 .44 , P<0 .01) .Con-clusion Both amisulpride and sulpiride an equivalent evident effect on schizophrenia ,but amisulpride has mild adverse reactions ,higher safety and better compliance .