CAJ | 학술논문

目的：探讨帕罗西汀联合米氮平治疗难治性抑郁症的疗效和安全性。方法将56例难治性抑郁症患者分为两组，均口服帕罗西汀治疗，研究组在此基础上联合米氮平治疗，观察8周。于治疗前后采用汉密顿抑郁量表、汉密顿焦虑量表、副反应量表评定疗效和不良反应。结果治疗8周末研究组显效率为67．9％、总有效率为92．9％，对照组分别为25．0％、78．6％，研究组显效率显著高于对照组（ P＜0．01）。研究组不良反应发生率为35．7％，对照组为32．1％，两组比较差异无显著性（P＞0．05）。结论帕罗西汀联合米氮平治疗难治性抑郁症起效快，疗效显著，安全性高，优于单用帕罗西汀治疗。
목적：탐토파라서정연합미담평치료난치성억욱증적료효화안전성。방법장56례난치성억욱증환자분위량조，균구복파라서정치료，연구조재차기출상연합미담평치료，관찰8주。우치료전후채용한밀돈억욱량표、한밀돈초필량표、부반응량표평정료효화불량반응。결과치료8주말연구조현효솔위67．9％、총유효솔위92．9％，대조조분별위25．0％、78．6％，연구조현효솔현저고우대조조（ P＜0．01）。연구조불량반응발생솔위35．7％，대조조위32．1％，량조비교차이무현저성（P＞0．05）。결론파라서정연합미담평치료난치성억욱증기효쾌，료효현저，안전성고，우우단용파라서정치료。
Objective To explore the efficacy and safety of paroxetine combined with mirtazapine in the treatment of treatment-resistant depression (TRD) .Methods Fifty-six TRD pa-tients were divided into two groups taking orally paroxetine ,on this basis research group was plus mirtaza-pine for 8 weeks .Before and after treatment efficacies were assessed with the Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA ) and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results At the end of the 8th week obvious and total effective rate were respec-tively 67 .9% and 92 .9% in research and 25 .0% and 78 .6% in control group ,obvious effective rate was significantly higher in research than in control group (P<0 .01) .The incidence of adverse reaction was re-spectively 35 .7% in research and 32 .1% in control group and had no significant group difference ( P>0 .05) .Conclusion Paroxetine combined with mirtazapine in the treatment of TRD takes effect more rap-idly and has an evident effect and higher safety compared with single paroxetine .