临床心身疾病杂志
臨床心身疾病雜誌
림상심신질병잡지
JOURNAL OF CLINICAL PSYCHOSOMATIC DISEASES
2014年
4期
4-7
,共4页
2型糖尿病%心身疾病%认知功能障碍%炎症因子%简易精神状态量表%蒙特利尔认知评估量表%韦氏成人智力量表
2型糖尿病%心身疾病%認知功能障礙%炎癥因子%簡易精神狀態量錶%矇特利爾認知評估量錶%韋氏成人智力量錶
2형당뇨병%심신질병%인지공능장애%염증인자%간역정신상태량표%몽특리이인지평고량표%위씨성인지역량표
T2DM%psychosomatic disease%cognitive dysfunction%inflammatory factor%MMSE%MoCA%WAIS
目的：探讨老年2型糖尿病患者认知功能障碍与炎症因子的相关性。方法将40例老年2型糖尿病伴认知功能障碍患者设为A组，40例无认知功能障碍的老年2型糖尿病患者设为B组，抽取同期进行健康体检的年龄≥60岁的健康志愿者38例设为C组。采用简易精神状态量表、蒙特利尔认知评估量表、韦氏成人智力量表评定认知功能，检测3组各项生化指标和炎症因子水平，并进行相关分析。结果 A组和B组患者空腹血糖、糖化血红蛋白、超敏C反应蛋白、白细胞介素-6、肿瘤坏死因子水平均显著高于C组（ P＜0．05或0．01），且A组均显著高于B组（ P＜0．05或0．01）；A组简易精神状态量表、蒙特利尔认知评估量表、韦氏成人智力量表总分及简易精神状态量表视空间与执行功能、注意、延迟回忆和定向因子分均显著低于B组和C组（P＜0．01）；A组认知功能障碍与糖化血红蛋白、白细胞介素-6、肿瘤坏死因子水平显著相关（ P＜0．05或0．01）。结论糖化血红蛋白、白细胞介素-6、肿瘤坏死因子是2型糖尿病合并认知功能障碍的重要影响因素。
目的：探討老年2型糖尿病患者認知功能障礙與炎癥因子的相關性。方法將40例老年2型糖尿病伴認知功能障礙患者設為A組，40例無認知功能障礙的老年2型糖尿病患者設為B組，抽取同期進行健康體檢的年齡≥60歲的健康誌願者38例設為C組。採用簡易精神狀態量錶、矇特利爾認知評估量錶、韋氏成人智力量錶評定認知功能，檢測3組各項生化指標和炎癥因子水平，併進行相關分析。結果 A組和B組患者空腹血糖、糖化血紅蛋白、超敏C反應蛋白、白細胞介素-6、腫瘤壞死因子水平均顯著高于C組（ P＜0．05或0．01），且A組均顯著高于B組（ P＜0．05或0．01）；A組簡易精神狀態量錶、矇特利爾認知評估量錶、韋氏成人智力量錶總分及簡易精神狀態量錶視空間與執行功能、註意、延遲迴憶和定嚮因子分均顯著低于B組和C組（P＜0．01）；A組認知功能障礙與糖化血紅蛋白、白細胞介素-6、腫瘤壞死因子水平顯著相關（ P＜0．05或0．01）。結論糖化血紅蛋白、白細胞介素-6、腫瘤壞死因子是2型糖尿病閤併認知功能障礙的重要影響因素。
목적：탐토노년2형당뇨병환자인지공능장애여염증인자적상관성。방법장40례노년2형당뇨병반인지공능장애환자설위A조，40례무인지공능장애적노년2형당뇨병환자설위B조，추취동기진행건강체검적년령≥60세적건강지원자38례설위C조。채용간역정신상태량표、몽특리이인지평고량표、위씨성인지역량표평정인지공능，검측3조각항생화지표화염증인자수평，병진행상관분석。결과 A조화B조환자공복혈당、당화혈홍단백、초민C반응단백、백세포개소-6、종류배사인자수평균현저고우C조（ P＜0．05혹0．01），차A조균현저고우B조（ P＜0．05혹0．01）；A조간역정신상태량표、몽특리이인지평고량표、위씨성인지역량표총분급간역정신상태량표시공간여집행공능、주의、연지회억화정향인자분균현저저우B조화C조（P＜0．01）；A조인지공능장애여당화혈홍단백、백세포개소-6、종류배사인자수평현저상관（ P＜0．05혹0．01）。결론당화혈홍단백、백세포개소-6、종류배사인자시2형당뇨병합병인지공능장애적중요영향인소。
Objective To investigate the correlation between cognitive impairment and inflammatory fac-tor’s levels elderly patients with type 2 diabetes mellitus (T2DM ) .Methods Forty T2DM elderly patients with cognitive impairment were assigned to group A ,40 ones without to B ,and 38 healthy volunteers aged≥60 selected from persons experiencing health examination in corresponding period to C .Cognitive func-tions were assessed with the Mini-mental State Examination (MMSE) ,Montreal Cognitive Assessment (MoCA) and Wechsler Adult Intelligence Scale (WAIS) ,all biochemical indicators and inflammatory fac-tors’ levels of three groups detected ,and correlation analyses carried out .Results Levels of serum FBG , HbAlc ,hs-CRP ,IL-6 ,TNF-αof group A and B were all significantly higher than those in C (P<0 .05 or 0 .01) and so were those in A than in B (P<0 .05 or 0 .01);the total score of the MMSE ,MoCA and WAIS as well as visual space ,executive function ,attention ,delayed recall and orientation score of the MMSE were all significantly lower in groups A than in B and C (P<0 .01);cognitive dysfunction was sig-nificantly related to HbAlc ,hs-CRP ,IL-6 ,TNF-α levels in group A (P<0 .05 or 0 .01) .Conclusion HbAlc ,IL-6 and TNF-αare important influencing factors of type 2 diabetes mellitus complicated with cog-nitive dysfunction .
