CAJ | 학술논문

富血小板血纤蛋白（PRF）制备简便，不需要加抗凝剂，无伦理道德争议及血液交叉感染。其立体三维结构使得PRF较富血小板血浆更坚实稳定。PRF为血管化的天然诱导物，其结构为免疫反应提供了天然支持，会影响上皮细胞和成纤维细胞的新陈代谢。其内的白细胞通过释放高质量分数的促炎因子白细胞介素-1β、4、6以及肿瘤坏死因子α和血管内皮生长因子，在抗感染、促组织愈合过程中起着重要的作用。PRF具有良好的骨诱导性，在即刻种植中将其用于辅助上颌窦提升，上颌窦骨密度和骨增量良好。PRF有利于骨髓间质干细胞的早期增殖和向成骨细胞的早期分化，明显促进人成骨细胞成骨相关有机基质分泌，促进成骨细胞早期成骨，抑制破骨细胞活化。本文就PRF的生物组成和功能，即诱导成骨、促软组织修复、促血管化和抗感染等研究进展作一综述。
부혈소판혈섬단백（PRF）제비간편，불수요가항응제，무윤리도덕쟁의급혈액교차감염。기입체삼유결구사득PRF교부혈소판혈장경견실은정。PRF위혈관화적천연유도물，기결구위면역반응제공료천연지지，회영향상피세포화성섬유세포적신진대사。기내적백세포통과석방고질량분수적촉염인자백세포개소-1β、4、6이급종류배사인자α화혈관내피생장인자，재항감염、촉조직유합과정중기착중요적작용。PRF구유량호적골유도성，재즉각충식중장기용우보조상합두제승，상합두골밀도화골증량량호。PRF유리우골수간질간세포적조기증식화향성골세포적조기분화，명현촉진인성골세포성골상관유궤기질분비，촉진성골세포조기성골，억제파골세포활화。본문취PRF적생물조성화공능，즉유도성골、촉연조직수복、촉혈관화화항감염등연구진전작일종술。
Platelet-rich?fibrin(PRF)?has?many?advantages,?such?as?easy?preparation?with?no?anticoagulant,?no?ethical?controversy,?and?no?blood?cross-infection.?Moreover,?its?three-dimensional?structure?makes?PRF?more?solid?and?stable?than?platelet-rich?plasma.?PRF?serves?as?a?natural?inducer?of?angiogenesis,?and?its?structure?provides?natural?support?for?immune?responses.?PRF?can?influence?the?metabolism?of?epithelial?cells?and?fibroblasts.?Leukocytes?within?PRF?have?important?functions?in?resistance?to?infection?and?promotion?of?the?tissue?healing?process?by?releasing?high?mass?fractions?of pro-inflammatory cytokines, including interleukin-1β, 4, 6, tumor necrosis factorα, and vascular endothelial growth factor.?PRF?exhibits?good?properties?of?osteoinduction,?which?is?used?to?assist?maxillary?sinus?lift?surgery?in?immediate?implantation,?and?has?beneficial?effects?on?bone?mineral?density?and?bone?increment.?PRF?is?conducive?to?the?proliferation?of?bone?marrow?mesenchymal?stem?cells?and?differentiation?into?osteoblasts?during?the?early?phase.?PRF?can?induce?human?osteoblasts?to?secrete?osteogenesis-related?organic?matrix,?promote?bone?formation?induced?by?osteoblasts,?and?inhibit?osteoclast?activation.?This?paper?reviews?the?cytokine?composition?and?macrobiological?functions?of?PRF,?such?as?osteoinduction,?soft?tissue?repair?promotion,?angiogenesis,?and?anti-infection?activities.