CAJ | 학술논문

滤泡样树突细胞分泌蛋白（FDC-SP）是一种由滤泡样树突细胞产生的可锚定于B细胞表面的蛋白质，其基因定位于4q13富含脯氨酸的唾液多肽和半胱氨酸-X-半胱氨酸趋化因子基因簇染色体4开放阅读框7附近，既可调节抗体应答、B细胞趋化，亦可参与防御功能。FDC-SP表达于淋巴生发中心亮区，还表达于白细胞浸润的扁桃体隐窝以及脂多糖（LPS）、金黄色葡萄球菌Cowan-1株活化的白细胞中，也表达于牙龈沟内结合上皮，体现其在口腔自然免疫防御过程中的重要性。在口腔中，FDC-SP正向调节牙周膜细胞的增殖并通过表皮生长因子受体信号转导途径抑制成纤维细胞分化为矿化组织细胞，作为口腔自然免疫防御的结合上皮的特异性标志分子，其表达水平与LPS息息相关，可通过对其的定位和定量测定揭示牙周健康状况及牙周疾病的进展。
려포양수돌세포분비단백（FDC-SP）시일충유려포양수돌세포산생적가묘정우B세포표면적단백질，기기인정위우4q13부함포안산적타액다태화반광안산-X-반광안산추화인자기인족염색체4개방열독광7부근，기가조절항체응답、B세포추화，역가삼여방어공능。FDC-SP표체우림파생발중심량구，환표체우백세포침윤적편도체은와이급지다당（LPS）、금황색포도구균Cowan-1주활화적백세포중，야표체우아간구내결합상피，체현기재구강자연면역방어과정중적중요성。재구강중，FDC-SP정향조절아주막세포적증식병통과표피생장인자수체신호전도도경억제성섬유세포분화위광화조직세포，작위구강자연면역방어적결합상피적특이성표지분자，기표체수평여LPS식식상관，가통과대기적정위화정량측정게시아주건강상황급아주질병적진전。
Follicular?dendritic?cell?secretory?protein(FDC-SP)?is?a?protein?generated?by?a?follicular?dendritic?cell.?FDC-SP?can?bind?to?the?surface?of?B?cells?whose?gene?lies?on?chromosome?4q13?adjacent?to?the?clusters?of?proline-rich?salivary?peptides.?Cysteine-X-Cysteine?chemokine,?which?is?adjacent?to?chromosome?4?open?reading?frame?7,?not?only?regulates?the?antibody?response?and?B?cell?chemotaxis?but?is?also?involved?in?the?innate?immune?response.?FDC-SP?is?expressed?in?the?light?zone?of?germinal-center?leukocyte-infiltrated?tonsil?crypts?by?lipopolysaccharide(LPS),?Staphylococcus aureus Cowan?strain?1-activated?leukocytes,?or?junctional?epithelium?in?the?oral?cavity.?FDC-SP?is?therefore?significant?in?oral?innate?immunity.?In?addition,?FDC-SP?positively?affects?the?proliferation?of?periodontal?ligament?cells?and?inhibits?their?differentiation?into?the?mineralized?tissue?cells?of?fibroblasts?through?the?epidermal?growth?factor?receptor?signal?transduction?pathway.?As?a?specific?biomarker?of?junctional?epithelium?in?oral?innate?immunity,?the?expression?of?FDC-SP?is?closely?related?to?LPS?level.?Reports?suggest?that?the?periodontal?health?status?and?progress?of?periodontitis?can?be?determined?by?the?location?or?quantification?of?FDC-SP.