CAJ | 학술논문

钛表面自身纳米化是指采用各种化学或物理方法增加钛表面的自由能，粗晶结构逐渐细化至纳米量级结构，基体与纳米结构层无明显的界面，材料外形尺寸基本保持不变。阳极氧化法和酸碱法为其常用技术。钛表面涂层或沉积纳米化是将制备好的纳米颗粒固结在钛表面，以形成一个与基体化学成分相同或不同的纳米结构表层，表层与基体之间存在界面且材料的外形尺寸有所增加。实现表层与基体之间以及表层纳米颗粒之间的牢固结合，是钛表面涂层或沉积纳米化的关键。钛表面自身纳米化以及表面涂层或沉积纳米化处理能明显增加钛种植体与骨组织的结合能力，促进骨整合，提高种植体成功率；而蛋白质吸附、细胞表面整联蛋白信号传递、单个细胞机械特性改变等，是钛表面纳米化处理影响骨结合的主要因素。随着生物材料学的不断发展，表面纳米化有望在促进种植体周围骨新生、增加初期稳定性和提高远期成功率等方面取得突破，更好地为口腔种植临床服务。
태표면자신납미화시지채용각충화학혹물리방법증가태표면적자유능，조정결구축점세화지납미량급결구，기체여납미결구층무명현적계면，재료외형척촌기본보지불변。양겁양화법화산감법위기상용기술。태표면도층혹침적납미화시장제비호적납미과립고결재태표면，이형성일개여기체화학성분상동혹불동적납미결구표층，표층여기체지간존재계면차재료적외형척촌유소증가。실현표층여기체지간이급표층납미과립지간적뢰고결합，시태표면도층혹침적납미화적관건。태표면자신납미화이급표면도층혹침적납미화처리능명현증가태충식체여골조직적결합능력，촉진골정합，제고충식체성공솔；이단백질흡부、세포표면정련단백신호전체、단개세포궤계특성개변등，시태표면납미화처리영향골결합적주요인소。수착생물재료학적불단발전，표면납미화유망재촉진충식체주위골신생、증가초기은정성화제고원기성공솔등방면취득돌파，경호지위구강충식림상복무。
Nanoscale?modificatioin?of?titanium?surface?refers?to?every?chemical?or?physical?method?which?can?increase?the?free?energy?of?titanium?surface?and?refine?the?coarse?structure?into?nanoscale?without?obvious?interface?between?the?nanoscale?srtuctures?and?titanium?substrate?or?alteration?of?overall?dimensions.?Anodic?oxidation?and?acid-base?treatment?are?the?most?commonly?used?methods.?Coating?or?deposition?nanoscale?modificatioin?of?titanium?is?solidifying?nanoscale?particles?on?titanium?surface,?forming?a?nanoscale?layer?with?a?chemical?composition?identical?with?substrate?or?not.?There?is?a?notable?interface?between?the?layer?and?titanium?substrate.?Additionally,?an?increase?of?overall?dimensions?can?be?detected.?The?key?to?realizing?coating?or?deposition?nanoscale?modificatioins?of?titanium?lies?in?the?firmly?combined?nanoscale?particales?and?the?solid?combination?of?the?layer?and?titanium?substrate.?Nowadays,?nanoscale?surface?modification?of?titanium?has?become?an?important?research?direction,?which?can?change?the?adhesion,?proliferation?and?differentiation?of?osteoblasts,?thereby?affecting?the?osseointegration.?Additionally,?protein?adsorption,?signaling?transmission?of?integrin?and?change?of?cell?mechanical?properties?have?been?considered?as?the?main?factors?of?osseointegration.?This?review?summarized?the?effect?and?mechanism?on?osseointegration?of?titanium?with?nanoscale?surface?modification.