CAJ | 학술논문

目的：研究整合素β1（Itgβ1）在大鼠髁突软骨力学适应性改建过程中的表达变化，为进一步探索髁突软骨细胞的力学—生物学信号转导提供实验依据。方法60只Sprague-Dawley大鼠随机分为实验组与对照组，实验组全天佩戴下颌前伸装置。分别于1、3、7、14、21、28 d取双侧髁突，检测Itgβ1在髁突软骨细胞中的表达情况，测量结果以免疫组织化学评分（IHS）表示。结果 Itgβ1表达量在整个实验周期中均明显高于对照组，且实验组Itgβ1表达量随时间呈现规律性变化并与髁突改建过程相应。结论 Itgβ1在大鼠下颌功能前伸后的髁突软骨力学适应性改建过程中发挥重要作用。
목적：연구정합소β1（Itgβ1）재대서과돌연골역학괄응성개건과정중적표체변화，위진일보탐색과돌연골세포적역학—생물학신호전도제공실험의거。방법60지Sprague-Dawley대서수궤분위실험조여대조조，실험조전천패대하합전신장치。분별우1、3、7、14、21、28 d취쌍측과돌，검측Itgβ1재과돌연골세포중적표체정황，측량결과이면역조직화학평분（IHS）표시。결과 Itgβ1표체량재정개실험주기중균명현고우대조조，차실험조Itgβ1표체량수시간정현규률성변화병여과돌개건과정상응。결론 Itgβ1재대서하합공능전신후적과돌연골역학괄응성개건과정중발휘중요작용。
Objective This study aims to investigate the expression of integrinβ1(Itgβ1) in endochondral remodeling of?rats?and?provide?experiment?basis?to?the?regulation?mechanism?of?the?mandibular?condylar?cartilage.?Methods???A?total?of?60?male?Sprague-Dawley?rats?were?randomly?divided?into?experimental?and?control?groups.?In?the?experimental?group,?inclined?bite?plate?was?cemented?to?the?upper?central?incisors?of?the?rats?for?1?d.?Five?rats?were?executed?in?each?group?after?1,?3,?7,?14,?21,?and?28?d.?The?specimens?of?the?bilateral?temporomandibular?joints?were?subjected?to?hematoxylin–eosin?staining and immunohistochemistry against Itgβ1. Data were presented as immunohistochemical scores(IHS). Results??The?IHS of Itgβ1 inthe experimental group was significantly higher than that inthe control group, whereasthe changes were normal.?Conclusion Itgβ1 has a crucial function in the reconstruction of the condylar cartilage during mandibular forward positioning.