CAJ | 학술논문

目的：考察注射用硝普钠与氯化钠注射液配伍的稳定性。方法将注射用硝普钠，根据临床应用需要配制成溶液，考察在不同环境下，不同放置时间硝普钠溶液的稳定性，包括溶液性状、pH、不溶微粒、紫外-可见吸收光谱、硝普钠含量等。结果避光套避光，在20℃或35℃时，注射用硝普钠与氯化钠注射液混合后26h 内是稳定的；不避光任何条件下溶液均不稳定；溶液的稳定性与浓度及温度无关，与光照和强度与时间密切相关。结论在避光条件下，注射用硝普钠与氯化钠注射液配伍26h 内稳定。
목적：고찰주사용초보납여록화납주사액배오적은정성。방법장주사용초보납，근거림상응용수요배제성용액，고찰재불동배경하，불동방치시간초보납용액적은정성，포괄용액성상、pH、불용미립、자외-가견흡수광보、초보납함량등。결과피광투피광，재20℃혹35℃시，주사용초보납여록화납주사액혼합후26h 내시은정적；불피광임하조건하용액균불은정；용액적은정성여농도급온도무관，여광조화강도여시간밀절상관。결론재피광조건하，주사용초보납여록화납주사액배오26h 내은정。
Objective To investigate the compatible stability of nitroprusside sodium for injection(SNP) when mixed with sodium chloride injection. Methods SNP was prepared into solution according to clinical use. The stability of SNP solution was studied in different environment and at different time, including appearance, pH value, insoluble particle, ultraviolet-visible absorption and SNP content. Results SNP solutions of sodium chloride injection were stable for 26 hours after preparation in shading circumstances at 20℃ or 35℃.Under the direct incandescent lamp without lightproof covering or shading circumstances, the solution was very unstable. Conclusion In the dark condition, SNP was stable within 26h after mixing with sodium chloride injection.