医学影像学杂志
醫學影像學雜誌
의학영상학잡지
JOURNAL OF MEDICAL IMAGING
2014年
6期
1049-1054
,共6页
王心%朱斌%张冰%张庆雷
王心%硃斌%張冰%張慶雷
왕심%주빈%장빙%장경뢰
2型糖尿病%磁共振波谱%脂肪含量%相关分析
2型糖尿病%磁共振波譜%脂肪含量%相關分析
2형당뇨병%자공진파보%지방함량%상관분석
Type 2 diabetes mellitus%MRS%Fat content%Correlation analysis
目的:利用双回波同反相位技术(DEI)、磁共振波谱技术(MRS)等方法评价2型糖尿病(T2DM)患者脂肪组织分布,并探讨其影响因素。方法对58例T2 DM 患者进行人体学特征、血生化指标检测及磁共振扫描,测量肝脏脂肪含量、骨骼肌细胞内、外脂肪含量、腹壁皮下脂肪面积、腹腔内脂肪面积及腹部脂肪总面积。将不同部位脂肪含量进行单因素和多因素回归分析。结果餐后2h血糖(2hPPG)、腹腔内脂肪面积(VAT)、腹部脂肪总面积(TA)、肝脏脂肪变指数(HFF)、肝脏相对脂肪含量(RLC)在是否合并脂肪肝组间有明显差异( P <0.05),身体质量指数(BMI)与脂肪面积指标(VAT、SAT、TA)及肝脏脂肪含量指标(HFF、RLC)呈明显正相关( P <0.01),且对脂肪面积指标(VAT、SAT、TA)有正向影响;2hPPG与VAT、TA呈正相关( P <0.05),2hPPG对VAT有正向影响,总胆固醇(TC)、低密度脂蛋白(LDL)与VAT、TA呈正相关( P <0.05);丙氨酸转氨酶(ALT)与HFF、RLC呈正相关。结论对于 T2DM 患者应积极预防、治疗脂肪肝,磁共振能更好的检测异位脂质。
目的:利用雙迴波同反相位技術(DEI)、磁共振波譜技術(MRS)等方法評價2型糖尿病(T2DM)患者脂肪組織分佈,併探討其影響因素。方法對58例T2 DM 患者進行人體學特徵、血生化指標檢測及磁共振掃描,測量肝髒脂肪含量、骨骼肌細胞內、外脂肪含量、腹壁皮下脂肪麵積、腹腔內脂肪麵積及腹部脂肪總麵積。將不同部位脂肪含量進行單因素和多因素迴歸分析。結果餐後2h血糖(2hPPG)、腹腔內脂肪麵積(VAT)、腹部脂肪總麵積(TA)、肝髒脂肪變指數(HFF)、肝髒相對脂肪含量(RLC)在是否閤併脂肪肝組間有明顯差異( P <0.05),身體質量指數(BMI)與脂肪麵積指標(VAT、SAT、TA)及肝髒脂肪含量指標(HFF、RLC)呈明顯正相關( P <0.01),且對脂肪麵積指標(VAT、SAT、TA)有正嚮影響;2hPPG與VAT、TA呈正相關( P <0.05),2hPPG對VAT有正嚮影響,總膽固醇(TC)、低密度脂蛋白(LDL)與VAT、TA呈正相關( P <0.05);丙氨痠轉氨酶(ALT)與HFF、RLC呈正相關。結論對于 T2DM 患者應積極預防、治療脂肪肝,磁共振能更好的檢測異位脂質。
목적:이용쌍회파동반상위기술(DEI)、자공진파보기술(MRS)등방법평개2형당뇨병(T2DM)환자지방조직분포,병탐토기영향인소。방법대58례T2 DM 환자진행인체학특정、혈생화지표검측급자공진소묘,측량간장지방함량、골격기세포내、외지방함량、복벽피하지방면적、복강내지방면적급복부지방총면적。장불동부위지방함량진행단인소화다인소회귀분석。결과찬후2h혈당(2hPPG)、복강내지방면적(VAT)、복부지방총면적(TA)、간장지방변지수(HFF)、간장상대지방함량(RLC)재시부합병지방간조간유명현차이( P <0.05),신체질량지수(BMI)여지방면적지표(VAT、SAT、TA)급간장지방함량지표(HFF、RLC)정명현정상관( P <0.01),차대지방면적지표(VAT、SAT、TA)유정향영향;2hPPG여VAT、TA정정상관( P <0.05),2hPPG대VAT유정향영향,총담고순(TC)、저밀도지단백(LDL)여VAT、TA정정상관( P <0.05);병안산전안매(ALT)여HFF、RLC정정상관。결론대우 T2DM 환자응적겁예방、치료지방간,자공진능경호적검측이위지질。
Objective To evaluate the adipose tissue distribution of type 2 diabetes mellitus( T2DM) patients with dual-echo in-phase and out-of-phase MR imaging (DEI) and magnetic resonance spectroscopy (MRS) and to investigate the in-fluencing factors .Methods 58 T2DM patients underwent anthroposomatology test ,blood biochemical tests and MR to test their hepatic lipid contents ,skeletal muscle intramyoelluar ,extramyocellular lipid contents ,subcutaneous adipose tis-sue (SAT) ,visceral adipose tissue (VAT) and total abdominal adipose tissue (TA) .Results There is significant differ-ence ( P <0 .05) between patients with fatty liver and patients without fatty liver in 2h PPG ,VAT ,TA ,hepatic fat frac-tion (HFF) and hepatic relative lipid content (RLC);BMI is positively related ( P <0 .01) with adipose tissue indexes (VAT ,SAT and TA) and liver lipid contents indexes (HFF ,RLC) ,and has positive influence on adipose tissue indexes (VAT ,SAT and TA);2h PPG is positively related ( P <0 .05) with VAT and TA and has positive influence on VAT ;total cholesterol (TC) and low density lipoprotein (LDL) is positively related with VAT and TA ( P < 0 .05);alanine transaminase (ALT) is positively related with HFF and RLC .Conclusion Active prevention and treatment against fatty liver should be made for T2DM patients ,and MR can be better in detecting ectopic lipids .