CAJ | 학술논문

目的：探讨血清孕酮、HCG联合检测在早期先兆流产诊断中的临床意义，为早期先兆流产的诊断提供理论依据。方法选取2010年4月至2012年6月间来我院就诊并治疗的早期先兆流产患者236例为研究组，同时选取正常孕妇70例作为对照组，记录两组患者血清孕酮及β-HCG的含量，同时对比评价孕酮单独检测与孕酮、β-HCG联合检测在早期先兆性流产诊断中的应用效果。结果早期先兆流产患者血清孕酮及β-HCG水平较对照组正常孕妇显著降低(P<0.01)；孕酮、β-HCG联合检测诊断早期先兆性流产的敏感性、阴性预测值以及诊断准确率与孕酮单独检测结果相比显著升高(P<0.05)，而对于特异性和阳性预测值而言，孕酮、β-HCG联合检测较孕酮单独检测略有下降，但两组患者间差异无统计学意义(P>0.05)。结论血清孕酮、β-HCG对于早期先兆流产的诊断具有指导意义；血清孕酮与β-HCG联合检测能够提高早期先兆流产患者妊娠结局预测的敏感性和准确率，有效指导患者的治疗，提高治疗效果，减少患者的经济负担。
목적：탐토혈청잉동、HCG연합검측재조기선조유산진단중적림상의의，위조기선조유산적진단제공이론의거。방법선취2010년4월지2012년6월간래아원취진병치료적조기선조유산환자236례위연구조，동시선취정상잉부70례작위대조조，기록량조환자혈청잉동급β-HCG적함량，동시대비평개잉동단독검측여잉동、β-HCG연합검측재조기선조성유산진단중적응용효과。결과조기선조유산환자혈청잉동급β-HCG수평교대조조정상잉부현저강저(P<0.01)；잉동、β-HCG연합검측진단조기선조성유산적민감성、음성예측치이급진단준학솔여잉동단독검측결과상비현저승고(P<0.05)，이대우특이성화양성예측치이언，잉동、β-HCG연합검측교잉동단독검측략유하강，단량조환자간차이무통계학의의(P>0.05)。결론혈청잉동、β-HCG대우조기선조유산적진단구유지도의의；혈청잉동여β-HCG연합검측능구제고조기선조유산환자임신결국예측적민감성화준학솔，유효지도환자적치료，제고치료효과，감소환자적경제부담。
Objective To investigate the clinical significance of the serum progesterone and HCG combined detection in the early diagnosis of threatened abortion, to provide a theoretical basis for the early diagnosis of threatened abortion. Methods 236 patients with threatened abortion in our hospital from April 2010 to June 2012 were selected as study group and 70 normal pregnant women were selected as control group. The primary outcome was a composite of levels of serum progesterone andβ-HCG, and a comparative evaluation of serum progesterone testing and progesterone andβ-HCG combined detection in early diagnosis of threatened abortion application. Results Serum progesterone andβ-HCG levels in patients with threatened abortion were significantly lower than those in the control group (P <0.01). The sensitivity, negative predictive value and diagnostic rate of the combined detection for diagnosing early threatened abortion were significantly higher than those of the serum progesterone detection (P <0.05), while the specificity and positive predictive value of the combined detection compared were lower than those of the serum progesterone detection , with no significant difference (P >0.05). Conclusions Serum progesterone andβ-HCG are highly instructive for early diagnosis of threatened abortion. The serum progesterone andβ-HCG combined detection can improve the sensitivity and accuracy of the prediction for the patients with threatened abortion, effectively guide the treatment, improve the therapeutic effect and reduce patients' economic burdens.