世界科学技术-中医药现代化
世界科學技術-中醫藥現代化
세계과학기술-중의약현대화
WORLD SCIENCE AND TECHNOLOGY-MODERNIZATION OF TRADITIONAL CHINESE MEDICINE
2014年
6期
1438-1441
,共4页
急性痛风性关节炎%肾功能衰竭%中药外敷%中药直肠滴入
急性痛風性關節炎%腎功能衰竭%中藥外敷%中藥直腸滴入
급성통풍성관절염%신공능쇠갈%중약외부%중약직장적입
Acute gouty arthritis%renal failure%external application of Chinese medicine%rectal instillation with Chinese medicine
目的：探讨中药外敷和直肠滴入治疗慢性肾衰竭伴急性痛风性关节炎的临床疗效。方法：将衡阳市第一人民医院82例的慢性肾衰竭伴急性痛风性关节炎患者随机分为研究组42例，采用中药外敷和直肠滴入治疗；对照组40例，采用泼尼松治疗。比较两组治疗后痛风关节的症状和体征，血尿酸、血肌酐、肌酐清除率，不良反应及复发率。结果：研究组与对照组缓解关节红肿疼痛方面疗效相近，差异无显著性。与治疗前相比，治疗后研究组血尿酸、血肌酐显著降低（P约0.01），肌酐清除率明显升高（P约0.05）；对照组治疗前后血肌酐、血尿酸、肌酐清除率比较无统计学意义。研究组未发现明显不良反应。随访1个月，中药研究组仅3例复发，明显优于对照组（P约0.01）。结论：中药外敷和直肠滴入治疗慢性肾衰竭伴痛风性关节炎疗效显著，复发率低，无明显不良反应，值得临床推广。
目的：探討中藥外敷和直腸滴入治療慢性腎衰竭伴急性痛風性關節炎的臨床療效。方法：將衡暘市第一人民醫院82例的慢性腎衰竭伴急性痛風性關節炎患者隨機分為研究組42例，採用中藥外敷和直腸滴入治療；對照組40例，採用潑尼鬆治療。比較兩組治療後痛風關節的癥狀和體徵，血尿痠、血肌酐、肌酐清除率，不良反應及複髮率。結果：研究組與對照組緩解關節紅腫疼痛方麵療效相近，差異無顯著性。與治療前相比，治療後研究組血尿痠、血肌酐顯著降低（P約0.01），肌酐清除率明顯升高（P約0.05）；對照組治療前後血肌酐、血尿痠、肌酐清除率比較無統計學意義。研究組未髮現明顯不良反應。隨訪1箇月，中藥研究組僅3例複髮，明顯優于對照組（P約0.01）。結論：中藥外敷和直腸滴入治療慢性腎衰竭伴痛風性關節炎療效顯著，複髮率低，無明顯不良反應，值得臨床推廣。
목적：탐토중약외부화직장적입치료만성신쇠갈반급성통풍성관절염적림상료효。방법：장형양시제일인민의원82례적만성신쇠갈반급성통풍성관절염환자수궤분위연구조42례，채용중약외부화직장적입치료；대조조40례，채용발니송치료。비교량조치료후통풍관절적증상화체정，혈뇨산、혈기항、기항청제솔，불량반응급복발솔。결과：연구조여대조조완해관절홍종동통방면료효상근，차이무현저성。여치료전상비，치료후연구조혈뇨산、혈기항현저강저（P약0.01），기항청제솔명현승고（P약0.05）；대조조치료전후혈기항、혈뇨산、기항청제솔비교무통계학의의。연구조미발현명현불량반응。수방1개월，중약연구조부3례복발，명현우우대조조（P약0.01）。결론：중약외부화직장적입치료만성신쇠갈반통풍성관절염료효현저，복발솔저，무명현불량반응，치득림상추엄。
This study was aimed to investigate the curative effect on external application and rectal instillation with Chinese medicine in the treatment of chronic renal failure (CRF) with acute gouty arthritis (GA). A total of 82 CRF patients with acute GA from the First People's Hospital of Hengyang City were randomly divided into the study group (n = 42), which was treated with external application and rectal instillation with Chinese medicine, and the control group (n = 40), which was treated with prednisone. The comparison was made on symptoms and body signs of GA, blood uric acid, creatinine, creatinine clearance, adverse reaction, and recurrence rate between two groups. The re-sults showed that there was no significant difference on alleviating of joint swelling and pain between the study group and the control group. Compared with pretreatment, the blood uric acid and creatinine were significantly decreased after treatment in the study group (P< 0.01). The creatinine clearance was obviously increased (P < 0.05). There were no significant differences on blood uric acid, creatinine and creatinine clearance in the control group before and after treatment. There was no adverse reaction in the study group. In the one-month follow-up, there were only three recurrent cases in the study group, which were obviously better than the control group (P< 0.01). It was concluded that external application and rectal instillation with Chinese medicine had a good curative effect on CRF with acute GA in the near future with low recurrence rate and no adverse reaction, which was worthy of popularizing in the clinical practice.
