CAJ | 학술논문

目的：探讨高血压脑出血患者血清雌二醇、睾酮水平与病情程度及预后的相关性。方法：检测168例高血压脑出血患者(脑出血组)及60例对照组血清雌二醇、睾酮的含量，按美国国立卫生研究院卒中量表标准对患者进行评分，再按病情轻重及病程评分的差值分组比较。结果：男性脑出血组雌二醇和睾酮与对照组差异均有统计学意义(P<0.01和P<0.05)，男女脑出血组雌二醇/睾酮比值与对照组差异均无统计学意义(P>0.05)。男性患者轻度病情组血清雌二醇含量较中、重度组升高(P<0.05)，男性3种病情组雌二醇/睾酮比值差异均无统计学意义(P>0.05)。男性患者少量出血组血清雌二醇和睾酮含量均较中量出血组升高(P<0.05)，男性3种出血组雌二醇/睾酮比值差异均无统计学意义(P>0.05)。女性脑出血组雌二醇与对照组差异无统计学意义(P>0.05)，女性脑出血组睾酮与对照组差异有统计学意义(P<0.05)，女性患者轻度病情组血清睾酮含量均较中、重度组显著升高(P<0.01)，女性轻度病情组雌二醇/睾酮比值均较中、重度组低(P<0.01和P<0.05)。女性患者少量出血组血清睾酮含量均较中、大量出血组明显升高(P<0.01)，女性患者血清雌二醇和雌二醇/睾酮比值不同出血量组差异均无统计学意义(P>0.05)。男、女性患者显著好转组雌二醇含量均较无变化组及恶化组升高(P<0.05~P<0.01)，男、女性患者显著好转组睾酮含量均较无变化组及恶化组下降(P<0.05~P<0.01)，男、女性患者显著好转组雌二醇/睾酮比值均较无变化组及恶化组升高(P<0.05~P<0.01)。结论：高血压脑出血患者血清雌二醇、雌二醇/睾酮比值测定有助于判断预后。
목적：탐토고혈압뇌출혈환자혈청자이순、고동수평여병정정도급예후적상관성。방법：검측168례고혈압뇌출혈환자(뇌출혈조)급60례대조조혈청자이순、고동적함량，안미국국립위생연구원졸중량표표준대환자진행평분，재안병정경중급병정평분적차치분조비교。결과：남성뇌출혈조자이순화고동여대조조차이균유통계학의의(P<0.01화P<0.05)，남녀뇌출혈조자이순/고동비치여대조조차이균무통계학의의(P>0.05)。남성환자경도병정조혈청자이순함량교중、중도조승고(P<0.05)，남성3충병정조자이순/고동비치차이균무통계학의의(P>0.05)。남성환자소량출혈조혈청자이순화고동함량균교중량출혈조승고(P<0.05)，남성3충출혈조자이순/고동비치차이균무통계학의의(P>0.05)。녀성뇌출혈조자이순여대조조차이무통계학의의(P>0.05)，녀성뇌출혈조고동여대조조차이유통계학의의(P<0.05)，녀성환자경도병정조혈청고동함량균교중、중도조현저승고(P<0.01)，녀성경도병정조자이순/고동비치균교중、중도조저(P<0.01화P<0.05)。녀성환자소량출혈조혈청고동함량균교중、대량출혈조명현승고(P<0.01)，녀성환자혈청자이순화자이순/고동비치불동출혈량조차이균무통계학의의(P>0.05)。남、녀성환자현저호전조자이순함량균교무변화조급악화조승고(P<0.05~P<0.01)，남、녀성환자현저호전조고동함량균교무변화조급악화조하강(P<0.05~P<0.01)，남、녀성환자현저호전조자이순/고동비치균교무변화조급악화조승고(P<0.05~P<0.01)。결론：고혈압뇌출혈환자혈청자이순、자이순/고동비치측정유조우판단예후。
Objective:To investigate the serum levels of estradiol and testosterone in patients with hypertensive intracerebral hemorrhage and their relations with illness severity and prognosis. Methods:The serum levels of estradiol and testosterone in 168 patients with hypertensive intracerebral hemorrhage ( cerebral hemorrhage group ) and 60 healthy people ( control group ) were determined. All patients were scored by U. S. National Institutes of Health Stroke Scale, and compared in two groups. Results:The differences of the serum levels of estradiol and testosterone in male between two groups were statistically significant(P<0. 01 and P<0. 05). The difference of the ratio of estradiol and testosteron serum level in male and female between two groups was not statistically significant(P>0. 05). The serum level of estradiol in male patient with mild illness was moderate,and high in severe patients(P<0. 05),the differences of the ratio of estradiol and testosteron serum level in three different illness severity male patients were not statistically significant(P>0. 05). The serum levels of estradiol and testosterone in male patients with small amount of bleeding were higher than those in male patients with median amount of bleeding(P<0. 05),the differences of the ratio of estradiol and testosteron serum level in three different bleeding male patients were not statistically significant(P>0. 05). The difference of the estradiol serum level in female between two groups was not statistically significant(P >0. 05),but for testosteron difference,it was statistically significant(P<0. 05). The serum level of testosteron in female patient with mild illness was moderate,and high in severe patients(P<0. 01),the ratio of estradiol and testosteron serum level in female mild patients was lower than that in moderate and severe female patients(P<0. 01 and P<0. 05). The serum level of testosterone in female patients with small amount of bleeding was higher than that in female patients with median and severe amount of bleeding(P<0. 05),the differences of the ratio of estradiol and testosteron serum level in different bleeding female patients were not statistically significant(P>0. 05). Compared with the no change and deterioration patients,the serum levels of estradiol and testosterone and the ratio of estradiol and testosterone in patients with obvious improvement were significantly increased,decreased and incresed,respectively(P<0. 05 to P<0. 01). Conclusions:The serum level of estradiol and ratio of estradiol and testosterone in patients with hypertensive intracerebral hemorrhage are helpful for judging the disease prognosis.