蚌埠医学院学报
蚌埠醫學院學報
방부의학원학보
ACTA ACADEMIAE MEDICINAE BENGBU
2014年
6期
741-744,748
,共5页
跟骨骨折%磷酸三钙%骨折,内固定
跟骨骨摺%燐痠三鈣%骨摺,內固定
근골골절%린산삼개%골절,내고정
calcaneal fracture%tricalcium phosphate%fracture,internal fixation
目的：观察多孔磷酸三钙治疗跟骨骨折的疗效及骨细胞生长情况。方法：85例跟骨骨折患者中，采取传统切口钢板内固定57例，小切口空心钉内固定28例，其中75例使用磷酸三钙植骨治疗，观察临床疗效。骨折愈合后二次手术取内固定，并在原植骨区取极少量骨组织标本再次行组织学观察，比较骨细胞的生长情况。结果：传统切口钢板内固定和小切口内固定植骨患者临床疗效明显优于小切口内固定未植骨患者(P<0.01)。植骨后新生骨组织中成骨细胞增生活跃，骨细胞分化成熟，密度增大，骨小梁密度增宽，骨小梁间纤维组织增生伴毛细血管增生。结论：多孔磷酸三钙具有良好的生物相容性、生物力学强度和骨传导作用，其降解效应与骨组织的改建塑形基本同步，降解速度适中，骨愈合后接近与正常骨组织，性能稳定，组织学照片显示新骨生成良好，与原骨组织相似。
目的：觀察多孔燐痠三鈣治療跟骨骨摺的療效及骨細胞生長情況。方法：85例跟骨骨摺患者中，採取傳統切口鋼闆內固定57例，小切口空心釘內固定28例，其中75例使用燐痠三鈣植骨治療，觀察臨床療效。骨摺愈閤後二次手術取內固定，併在原植骨區取極少量骨組織標本再次行組織學觀察，比較骨細胞的生長情況。結果：傳統切口鋼闆內固定和小切口內固定植骨患者臨床療效明顯優于小切口內固定未植骨患者(P<0.01)。植骨後新生骨組織中成骨細胞增生活躍，骨細胞分化成熟，密度增大，骨小樑密度增寬，骨小樑間纖維組織增生伴毛細血管增生。結論：多孔燐痠三鈣具有良好的生物相容性、生物力學彊度和骨傳導作用，其降解效應與骨組織的改建塑形基本同步，降解速度適中，骨愈閤後接近與正常骨組織，性能穩定，組織學照片顯示新骨生成良好，與原骨組織相似。
목적：관찰다공린산삼개치료근골골절적료효급골세포생장정황。방법：85례근골골절환자중，채취전통절구강판내고정57례，소절구공심정내고정28례，기중75례사용린산삼개식골치료，관찰림상료효。골절유합후이차수술취내고정，병재원식골구취겁소량골조직표본재차행조직학관찰，비교골세포적생장정황。결과：전통절구강판내고정화소절구내고정식골환자림상료효명현우우소절구내고정미식골환자(P<0.01)。식골후신생골조직중성골세포증생활약，골세포분화성숙，밀도증대，골소량밀도증관，골소량간섬유조직증생반모세혈관증생。결론：다공린산삼개구유량호적생물상용성、생물역학강도화골전도작용，기강해효응여골조직적개건소형기본동보，강해속도괄중，골유합후접근여정상골조직，성능은정，조직학조편현시신골생성량호，여원골조직상사。
Objective:To observe the clinical efficacy and bone cell growth of porous tricalcium phosphate in the treatment of calcaneal fracture. Methods:Eighty-five patients with calcaneal fractures were treated with steel plate internal fixation under traditional incision(57 cases) and cannulated screw internal fixation under small incision(28 cases). Seventy-five patients were treated with tricalcium phosphate bone graft,the clinical efficacy of which was observed. The internal fixation was removed after fracture healing. The bone specimens from the original graft area were harvested,the histological feature of which was observed,and the growth of bone cells was analyzed. Results:The clinical effects of patients treated with steel plate internal fixation under traditional incision and internal fixation with bone graft under small incision were significantly better than that in patients treated with internal fixation without bone graft under small incision(P <0. 01). In new bone tissue,osteoblasts active proliferating,mature bone cell differentiating,bone density increasing,bone trabecula density broadening and the fibrous tissue among bone trabecula complicated with capillary hyperplasia were detected. Conclusions:Porous tricalcium phosphate has good bio-compatibility,biomechanical strength and bone conduction effect,the biological degradation effect of which is synchronized with bone tissue reconstruction. The new bone tissue after fracture healing is similar to the normal bone. The growth of new bone is good,which is similar to the original bone tissue.
