CAJ | 학술논문

目的：观察健心平律丸联合小剂量胺碘酮对阵发性房颤患者脑钠肽(BNP)、醛固酮(Ald)的影响。方法采用随机分组对照方法,分为治疗组30例,对照组32例。观察对象2周内未服用抗心律失常药物及影响心率、心电图、血脂的药物。治疗组在对照组治疗基础上,服用健心平律丸6 g,每天3次。对照组服用胺碘酮,从200 mg,每天3次开始,5 d后减为200 mg,每天2次,再5 d后减为200 mg,每天1次维持。治疗开始前及治疗结束后记录主要症状(心悸、胸闷、气短、疲倦乏力、头晕、舌脉象)、证候(心阳不振、气阴两虚、痰瘀阻滞)、体征、心电图、BNP、Ald。结果治疗组与对照组阵发性房颤患者BNP、Ald治疗前无统计学意义(P>0.05)；治疗组用药3个月后,与治疗前比较,BNP、Ald有统计学意义(P<0.05)；用药3月后,治疗组与对照组 BNP、Ald 相比较有统计学意义(P<0.05)。结论健心平律丸联合小剂量胺碘酮能够降低阵发性房颤患者 BNP、Ald 水平,优于常规单用西药组,且无任何毒副反应。
목적：관찰건심평률환연합소제량알전동대진발성방전환자뇌납태(BNP)、철고동(Ald)적영향。방법채용수궤분조대조방법,분위치료조30례,대조조32례。관찰대상2주내미복용항심률실상약물급영향심솔、심전도、혈지적약물。치료조재대조조치료기출상,복용건심평률환6 g,매천3차。대조조복용알전동,종200 mg,매천3차개시,5 d후감위200 mg,매천2차,재5 d후감위200 mg,매천1차유지。치료개시전급치료결속후기록주요증상(심계、흉민、기단、피권핍력、두훈、설맥상)、증후(심양불진、기음량허、담어조체)、체정、심전도、BNP、Ald。결과치료조여대조조진발성방전환자BNP、Ald치료전무통계학의의(P>0.05)；치료조용약3개월후,여치료전비교,BNP、Ald유통계학의의(P<0.05)；용약3월후,치료조여대조조 BNP、Ald 상비교유통계학의의(P<0.05)。결론건심평률환연합소제량알전동능구강저진발성방전환자 BNP、Ald 수평,우우상규단용서약조,차무임하독부반응。
Objective To observe impact of Jianxin Pinglüpill(JPP)with a low dose of amiodarone on the levels of B type natri-uretic peptide (BNP)and aldosterone (Ald)in paroxysmal atrial fibrillation.Methods Sixty two patients were divided into the treatment group (n=30)treated with JPP,and control group (n=32)treated with amiodarone.Patients main symptoms (palpita-tions,chest tightness,shortness of breath,fatigue,dizziness,and tongue and pulse manifestations),syndromes (devitalization syn-dromes of heart yang,deficiency syndromes of both qi and yin,and phlegm accumulation stasis syndromes),physical signs,ECG, BNP and Ald were recorded before and after the treatment.Results Before the treatment,there was no difference in BNP,Ald in pa-tients with paroxysmal atrial fibrillation between the treatment group and the control group(P>0.05).After treatment,BNP and Ald in the treatment group was significant difference (P<0.05).After the three month treatment,a significant difference in BNP and Ald appeared between the treatment group and the control group (P<0.05).Conclusion JPP in combination with a low dose of ami-odarone could reduce BNP and Ald levels in paroxysmal atrial fibrillation.It was better than amiodarone.And it was a safe and effec-tive drug for paroxysmal atrial fibrillation.