CAJ | 학술논문

目的：探究糖尿病及其并发症患者体内左卡尼汀（L-carnitine，LC）、乙酰左卡尼汀（acetyl-L-carnitine，ALC）和丙酰左卡尼汀（propionyl-L-carnitine，PLC）的含量变化。方法复制柱前衍生化HPLC同时检测血浆中LC、ALC、PLC的含量的方法，检测并比较健康受试者、糖尿病患者以及糖尿病并发症患者（糖尿病视网膜病变、糖尿病肾病、糖尿病周围神经病变、糖尿病并高血压、糖尿病并冠心病）体内3种物质含量的变化。结果健康受试者、糖尿病患者以及糖尿病视网膜病变、糖尿病肾脏病变、糖尿病周围神经病变、糖尿病并高血压、糖尿病并冠心病患者血浆 LC 浓度分别为（41.01±8.05）μmol · L－1、（36.72±8.23）μmol · L－1、（33.31±6.26）μmol · L－1、（33.81±5.61）μmol · L－1、（33.57±6.67）μmol · L－1、（33.67±5.36）μmol · L－1、（32.87±6.05）μmol·L－1。糖尿病组的血浆LC 浓度明显低于健康对照组（P＜0.05），其他并发症组（糖尿病视网膜病变组、糖尿病肾脏病变组、糖尿病周围神经病变组、糖尿病并高血压和糖尿病并冠心病组）的LC浓度又明显低于糖尿病组，但各并发症的血浆LC 浓度组间比较无差异（P＞0.05），ALC和PLC的检测结果显示各组之间差异并没有显著性（P＞0.05）。结论在中国健康受试者、DM患者以及并发症患者中，DM患者的LC血浆浓度低于健康受试者，糖尿病并发症患者LC的血浆浓度低于DM患者。
목적：탐구당뇨병급기병발증환자체내좌잡니정（L-carnitine，LC）、을선좌잡니정（acetyl-L-carnitine，ALC）화병선좌잡니정（propionyl-L-carnitine，PLC）적함량변화。방법복제주전연생화HPLC동시검측혈장중LC、ALC、PLC적함량적방법，검측병비교건강수시자、당뇨병환자이급당뇨병병발증환자（당뇨병시망막병변、당뇨병신병、당뇨병주위신경병변、당뇨병병고혈압、당뇨병병관심병）체내3충물질함량적변화。결과건강수시자、당뇨병환자이급당뇨병시망막병변、당뇨병신장병변、당뇨병주위신경병변、당뇨병병고혈압、당뇨병병관심병환자혈장 LC 농도분별위（41.01±8.05）μmol · L－1、（36.72±8.23）μmol · L－1、（33.31±6.26）μmol · L－1、（33.81±5.61）μmol · L－1、（33.57±6.67）μmol · L－1、（33.67±5.36）μmol · L－1、（32.87±6.05）μmol·L－1。당뇨병조적혈장LC 농도명현저우건강대조조（P＜0.05），기타병발증조（당뇨병시망막병변조、당뇨병신장병변조、당뇨병주위신경병변조、당뇨병병고혈압화당뇨병병관심병조）적LC농도우명현저우당뇨병조，단각병발증적혈장LC 농도조간비교무차이（P＞0.05），ALC화PLC적검측결과현시각조지간차이병몰유현저성（P＞0.05）。결론재중국건강수시자、DM환자이급병발증환자중，DM환자적LC혈장농도저우건강수시자，당뇨병병발증환자LC적혈장농도저우DM환자。
Aim To investigate the changes of content of L-carnitine (LC ), acetyl-L-carnitine (ALC ) and propionyl-L-carnitine (PLC )in patients with diabetes and its complications.Methods By replicating meth-od of pre-column derivatization HPLC,the contents of plasma LC,ALC,PLC were detercted in normal sub-jects and in patients of diabetes mellitus,diabetic reti-nopathy, diabetic nephropathy, diabetic peripheral neuropathy,diabetic hypertension,diabetic coronary heart disease.Results The concentration of LC in normal subjects and in patients of diabetes mellitus, diabetic retinopathy, diabetic nephropathy, diabetic peripheral neuropathy,diabetic hypertension,diabetic coronary heart disease were (41.01 ±8.05 )μmol · L-1 ,(36.72 ±8.23 )μmol · L-1 ,(33.3 1 ±6.26 )μmol·L-1 ,(33.81 ±5.61 )μmol·L-1 ,(33.57 ± 6.67 )μmol · L-1 , (33.67 ±5.36 )μmol · L-1 , (32.87 ±6.05 )μmol · L-1 respectively.The plasma LC concentration in diabetic group was significantly lower than that of normal control group (P<0.05 ). Moreover,the LC concentration in other groups of dia-betic complications was lower than that in diabetic group, and LC concentration showed no significant difference in various groups of diabetic complications. There was no significant difference in the plasma con-centrations of ALC and PLC of diabetes group and the diabetic complication groups too.Conclusion In Chi-nese normal subjects,patients with diabetes and dia-betic complications,the plasma concentrations of LC in diabetic patients are lower than normal,and plasma concentration of LC in diabetic complications are lower than that in patients with diabetes mellitus.