CAJ | 학술논문

钙调素依赖性蛋白激酶Ⅱ（calcium／calmodulin-depend-ent protein kinase Ⅱ，CaMKⅡ）是一种在学习和记忆形成机制中具有重要作用的蛋白激酶，它存在于大多数组织中，但以神经元中表达量最高。大多数具有激酶活性的蛋白分子在组织中的表达量都相对较低，所以CaMKⅡ在神经系统中高度表达具有其特殊意义。该文将较为全面的对CaMKⅡ的分子结构与自身磷酸化特征、亚细胞空间定位及其在突触可塑性中的作用进行综述。
개조소의뢰성단백격매Ⅱ（calcium／calmodulin-depend-ent protein kinase Ⅱ，CaMKⅡ）시일충재학습화기억형성궤제중구유중요작용적단백격매，타존재우대다수조직중，단이신경원중표체량최고。대다수구유격매활성적단백분자재조직중적표체량도상대교저，소이CaMKⅡ재신경계통중고도표체구유기특수의의。해문장교위전면적대CaMKⅡ적분자결구여자신린산화특정、아세포공간정위급기재돌촉가소성중적작용진행종술。
Calcium/calmodulin-dependent protein kinase Ⅱ(CaMKⅡ),which is an important protein kinase involved in learning and memory,is found in most tissues,but it is present in especially high concentrations in neurons.The relatively high expression of CaMKⅡin nervous system suggests it plays an im-portant role in the function of nervous system.This paper re-views the research development of the molecular structure of CaMKⅡ and its autophosphorylation,subcellular localization and its role in synaptic plasticity.