CAJ | 학술논문

目的：建立中国食蟹猴脑结构T 1图像模板，分析其脑灰质、白质及脑脊液组织概率分布图。方法16只健康中国食蟹猴3．0T MRI脑的高分辨3D矢状位 T1WI采集，使用模糊C均值聚类（fuzzy c-meass clusteriag Algorithm ， FCM ）法对每例图像进行组织分割、插值、空间标准化及图像平滑，建立脑白质、灰质、脑脊液组织概率图和个体脑模板。对所得图像进行配准及平均后，再经过VBM流程分析测试获得食蟹猴M RI图像模板。结果建立了正常中国食蟹猴脑结构3D模板，并获得了食蟹猴脑白质、灰质、脑脊液三种组织的概率图，清晰地显示了全脑T1加权对比结构。结论建立M RI图像模板和组织概率图为中国食蟹猴脑结构VBM 分析和fM RI定位提供了重要的基础和便利。
목적：건립중국식해후뇌결구T 1도상모판，분석기뇌회질、백질급뇌척액조직개솔분포도。방법16지건강중국식해후3．0T MRI뇌적고분변3D시상위 T1WI채집，사용모호C균치취류（fuzzy c-meass clusteriag Algorithm ， FCM ）법대매례도상진행조직분할、삽치、공간표준화급도상평활，건립뇌백질、회질、뇌척액조직개솔도화개체뇌모판。대소득도상진행배준급평균후，재경과VBM류정분석측시획득식해후M RI도상모판。결과건립료정상중국식해후뇌결구3D모판，병획득료식해후뇌백질、회질、뇌척액삼충조직적개솔도，청석지현시료전뇌T1가권대비결구。결론건립M RI도상모판화조직개솔도위중국식해후뇌결구VBM 분석화fM RI정위제공료중요적기출화편리。
Objective To establish a T1 image template of the Chinese cynomolgus monkeys (Macaca fascicularis) brain and to perform a analysis brain tissue by developing a digital multi-atlas of grey matter ,whiter matter and cerebrospinal fluid .Methods Sixteen healthy Chinese cynomolgus monkeys were scanned by high resolution 3 .0 T Magnatic Resonance Imaging (MRI) to acquire sagittal 3D T1WI images .An individual brain template and tissue digital atlases of grey matter was conducted ,white matter and cerebrospinal fluid ;segmentation ,interpolation ,spatial normalization and image smoot-hing of the MRIs were carried out using the Fuzzy c-means Clustering Algorithm (FCM) .When co-registration and an av-erage on the reference images were performed ,cynomolgus monkeys brain atlases was then constructed after voxel-based morphometry (VBM) process analysis and testing of the multi-atlas .Results The 3D MRI template of healthy Chinese cynomolgus monkeys was established three tissue digital atlases of grey matter ,white matter and cerebrospinal fluid were developed ,distinctly indicating the whole brain T1-weighted contrast structure .Conclusion The construction of MRI template of the cynomolgus monkeys brain provides a foundation and convenience for brain functional orientation with fM-RI and brain structure analysis with VBM .