CAJ | 학술논문

目的：评估苦寒燥湿、活血通络法对活动期类风湿关节炎（RA）的临床疗效。方法选择100例活动期 RA 患者分为治疗组和对照组，治疗组予以三黄一龙汤联合注射用血塞通、非甾体抗炎药（NSAIDs）、非生物制剂抗风湿性药物（DMARDs）治疗，对照组予以 NSAIDs、DMARDs 治疗，两组均治疗2个疗程。观察治疗前后两组肿胀、压痛关节数，晨僵时间，评价握力及血小板、血沉、C 反应蛋白等指标。结果治疗组临床和实验室指标改善早于并优于对照组（P ﹤0.05）；治疗组治疗4、8 w 后，改善率分别为82％、94％，亦优于对照组的62％和80％（P ﹤0.05）。结论苦寒燥湿、活血通络法治疗 RA 活动期，能更好、更快地改善临床症状、体征和实验室指标，提高治疗效果，缩短住院时间。
목적：평고고한조습、활혈통락법대활동기류풍습관절염（RA）적림상료효。방법선택100례활동기 RA 환자분위치료조화대조조，치료조여이삼황일룡탕연합주사용혈새통、비치체항염약（NSAIDs）、비생물제제항풍습성약물（DMARDs）치료，대조조여이 NSAIDs、DMARDs 치료，량조균치료2개료정。관찰치료전후량조종창、압통관절수，신강시간，평개악력급혈소판、혈침、C 반응단백등지표。결과치료조림상화실험실지표개선조우병우우대조조（P ﹤0.05）；치료조치료4、8 w 후，개선솔분별위82％、94％，역우우대조조적62％화80％（P ﹤0.05）。결론고한조습、활혈통락법치료 RA 활동기，능경호、경쾌지개선림상증상、체정화실험실지표，제고치료효과，축단주원시간。
Objective To evaluate the clinical efficiency of the treatment of traditional Chinese medicine method of bitter-cold herbs easing dampness plus Xuesetong injection promoting blood circulation to remove meridian obstruction on active rheumatoid arthritis(RA). Methods 100 cases with active RA were divided into 2 groups:treatment group and control group,50 cases in each;NASIDs and DMARDs were administrated to the cases in both groups,while Sanhuang Yilong decoction and Xuesetong injection were added to cases in treatment group;the course lasted for 2 months;the clinical manifestation and laboratory indexes of the cases in both groups were observed and comparatively analyzed. Results An earlier and superior improvement in clinical manifestation and laboratory indexes was gained in treatment group than that in control group;the rates of improvement in treatment group at the time point of the 4 and 8 weeks after treatment were 82% and 94% ,respectively,much higher than those in control group(62% and 80%respectively)(P ﹤ 0. 05). Conclusions The treatment of bitter-cold herbs easing dampness plus promoting blood circulation to remove meridian obstruction is effective on active RA;it provides a better and faster improvement in clinical manifestation,physical signs and laboratory index so that the time for hospitalization is shortened.