实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2014年
7期
22-24
,共3页
高血压%动脉粥样硬化%颈动脉疾病%螺杆菌,幽门
高血壓%動脈粥樣硬化%頸動脈疾病%螺桿菌,幽門
고혈압%동맥죽양경화%경동맥질병%라간균,유문
Hypertension%Atherosclerosis%Carotid artery diseases%Helicobacter pylori
目的：探讨原发性高血压（EH）患者颈动脉粥样硬化（CAS）与幽门螺杆菌（Hp）感染的相关性。方法选择2012-2013年我院收治的 EH 患者150例为 EH 组，同期在我院体检健康者50例为对照组。检测两组受试者的颈动脉内膜中层厚度（CAIMT）、幽门螺杆菌抗体（Hp - IgG）、血脂及血清高敏 C 反应蛋白（hs - CRP）、同型半胱氨酸（HCY）水平。结果根据 CAIMT 和 Hp - IgG 检查结果将 EH 组患者分为 CAIMT 增厚组89例和 CAIMT 非增厚组61例，Hp 感染组67例和 Hp 非感染组83例。EH 组 CAIMT >1.0 mm 者所占比例（59.3%）和 Hp - IgG 阳性者所占比例（44.7%）均高于对照组（12.0%，28.0%）（P <0.05）。CAIMT 增厚组 Hp - IgG 阳性者所占比例（55.1%）高于 CAIMT 非增厚组（29.5%）（P <0.05），Hp 感染组 CAIMT >1.0 mm 者所占比例（73.1%）高于 Hp 非感染组（48.2%）（P <0.05）。直线相关分析结果显示，CAIMT 增厚与 Hp 感染率呈正相关（r ＝0.787，P <0.01）。Hp 感染组血清 TG、TC、LDL - C、HCY、hs - CRP高于 Hp 非感染组，HDL - C 水平低于 Hp 非感染组（P <0.01）。结论 EH患者 CAS 的发生与 Hp 感染有关，Hp 感染可能通过影响机体炎性反应、血脂代谢及 HCY 水平促进 CAS 的发生和发展，清除或预防 Hp 感染可能是防治 EH 患者发生 CAS 的策略之一。
目的：探討原髮性高血壓（EH）患者頸動脈粥樣硬化（CAS）與幽門螺桿菌（Hp）感染的相關性。方法選擇2012-2013年我院收治的 EH 患者150例為 EH 組，同期在我院體檢健康者50例為對照組。檢測兩組受試者的頸動脈內膜中層厚度（CAIMT）、幽門螺桿菌抗體（Hp - IgG）、血脂及血清高敏 C 反應蛋白（hs - CRP）、同型半胱氨痠（HCY）水平。結果根據 CAIMT 和 Hp - IgG 檢查結果將 EH 組患者分為 CAIMT 增厚組89例和 CAIMT 非增厚組61例，Hp 感染組67例和 Hp 非感染組83例。EH 組 CAIMT >1.0 mm 者所佔比例（59.3%）和 Hp - IgG 暘性者所佔比例（44.7%）均高于對照組（12.0%，28.0%）（P <0.05）。CAIMT 增厚組 Hp - IgG 暘性者所佔比例（55.1%）高于 CAIMT 非增厚組（29.5%）（P <0.05），Hp 感染組 CAIMT >1.0 mm 者所佔比例（73.1%）高于 Hp 非感染組（48.2%）（P <0.05）。直線相關分析結果顯示，CAIMT 增厚與 Hp 感染率呈正相關（r ＝0.787，P <0.01）。Hp 感染組血清 TG、TC、LDL - C、HCY、hs - CRP高于 Hp 非感染組，HDL - C 水平低于 Hp 非感染組（P <0.01）。結論 EH患者 CAS 的髮生與 Hp 感染有關，Hp 感染可能通過影響機體炎性反應、血脂代謝及 HCY 水平促進 CAS 的髮生和髮展，清除或預防 Hp 感染可能是防治 EH 患者髮生 CAS 的策略之一。
목적：탐토원발성고혈압（EH）환자경동맥죽양경화（CAS）여유문라간균（Hp）감염적상관성。방법선택2012-2013년아원수치적 EH 환자150례위 EH 조，동기재아원체검건강자50례위대조조。검측량조수시자적경동맥내막중층후도（CAIMT）、유문라간균항체（Hp - IgG）、혈지급혈청고민 C 반응단백（hs - CRP）、동형반광안산（HCY）수평。결과근거 CAIMT 화 Hp - IgG 검사결과장 EH 조환자분위 CAIMT 증후조89례화 CAIMT 비증후조61례，Hp 감염조67례화 Hp 비감염조83례。EH 조 CAIMT >1.0 mm 자소점비례（59.3%）화 Hp - IgG 양성자소점비례（44.7%）균고우대조조（12.0%，28.0%）（P <0.05）。CAIMT 증후조 Hp - IgG 양성자소점비례（55.1%）고우 CAIMT 비증후조（29.5%）（P <0.05），Hp 감염조 CAIMT >1.0 mm 자소점비례（73.1%）고우 Hp 비감염조（48.2%）（P <0.05）。직선상관분석결과현시，CAIMT 증후여 Hp 감염솔정정상관（r ＝0.787，P <0.01）。Hp 감염조혈청 TG、TC、LDL - C、HCY、hs - CRP고우 Hp 비감염조，HDL - C 수평저우 Hp 비감염조（P <0.01）。결론 EH환자 CAS 적발생여 Hp 감염유관，Hp 감염가능통과영향궤체염성반응、혈지대사급 HCY 수평촉진 CAS 적발생화발전，청제혹예방 Hp 감염가능시방치 EH 환자발생 CAS 적책략지일。
Objective To investigate the correlation between carotid artery atherosclerosis(CAS) and helicobacter pylori(Hp)infection in patients with essential hypertension(EH). Methods From 2012 to 2013,a total of 150 EH patients were chosen as research group,50 healthy cases were chosen as control group. The CAIMT,Hp - IgG,blood lipid and serum levels of hs - CRP,HCY were detected. Results 89 patients′CAIMT were larger than 1. 0 mm in research group while the other 61 patients were not,and 67 patients got Hp infection while the other 83 patients did not. The rates of CAIMT > 1. 0 mm (59. 3% ),Hp - IgG positive(44. 7% )in research group were higher than those in control group(12. 0% ,28. 0% )(P <0. 05). The rate of Hp - IgG positive(55. 1% )in patients whose CAIMT were larger than 1. 0 mm was higher than that in pa-tients whose CAIMT were not(29. 5% )(P < 0. 05);the rate of CAIMT > 1. 0 mm(73. 1% )in patients who got Hp infection was higher than that in patients who did not(48. 2% )(P < 0. 05). By linear correlation analysis,CAIMT was positively corre-lated with the rate of Hp infection in EH patients( r = 0. 787,P < 0. 01). Serum levels of TG,TC,LDL - C,HCY and hs - CRP were significantly higher in patients who got Hp infection than those in patients who did not(P < 0. 01),serum HDL -C level was significantly lower(P < 0. 01). Conclusion Onset of CAS is correlated with Hp infection in EH patients,it may affect the blood lipid metabolism,inflammatory reaction and HCY levels to promote the development of CAS,removement or pre-vention of Hp infection may be one of the strategies for preventing and treating CAS in EH patients.
