CAJ | 학술논문

目的：观察环磷腺苷葡胺（MAC）治疗老年慢性收缩性心力衰竭（CHF）的临床疗效及安全性。方法选择2011年9月-2013年9月我院住院治疗的老年 CHF 患者76例，将其随机分为常规治疗组37例和 MAC 组39例。两组均给予常规抗心力衰竭治疗，在此基础上 MAC 组患者给予 MAC 进行治疗，均以14 d 为1个疗程。比较两组疗效、治疗前后心功能指标〔包括左室舒张末期容积（LVEDV）、左室收缩末期容积（ LVESV）及左心室射血分数（LVEF）〕和 B 型利钠肽（BNP）水平变化情况，并记录药物不良反应。结果 MAC 组患者治疗总有效率为94.9%（37/39），高于常规治疗组的70.2%（26/37）（P <0.05）。治疗前两组患者 LVEDV、LVESV、LVEF 和 BNP 比较，差异均无统计学意义（P >0.05）。治疗后 MAC 组患者 LVEF 高于常规治疗组，BNP 水平低于常规治疗组（ P <0.05）；两组患者 LVEDV 和 LVESV 比较，差异均无统计学意义（P >0.05）。治疗期间 MAC 组患者未发生严重不良反应。结论 MAC 治疗老年 CHF 疗效显著，能有效增强心肌收缩力，减轻心力衰竭症状且安全性好。
목적：관찰배린선감포알（MAC）치료노년만성수축성심력쇠갈（CHF）적림상료효급안전성。방법선택2011년9월-2013년9월아원주원치료적노년 CHF 환자76례，장기수궤분위상규치료조37례화 MAC 조39례。량조균급여상규항심력쇠갈치료，재차기출상 MAC 조환자급여 MAC 진행치료，균이14 d 위1개료정。비교량조료효、치료전후심공능지표〔포괄좌실서장말기용적（LVEDV）、좌실수축말기용적（ LVESV）급좌심실사혈분수（LVEF）〕화 B 형리납태（BNP）수평변화정황，병기록약물불량반응。결과 MAC 조환자치료총유효솔위94.9%（37/39），고우상규치료조적70.2%（26/37）（P <0.05）。치료전량조환자 LVEDV、LVESV、LVEF 화 BNP 비교，차이균무통계학의의（P >0.05）。치료후 MAC 조환자 LVEF 고우상규치료조，BNP 수평저우상규치료조（ P <0.05）；량조환자 LVEDV 화 LVESV 비교，차이균무통계학의의（P >0.05）。치료기간 MAC 조환자미발생엄중불량반응。결론 MAC 치료노년 CHF 료효현저，능유효증강심기수축력，감경심력쇠갈증상차안전성호。
Objective To study the effect of meglumine adenosine cyclophate(MAC)on aged patients with chronic systolic heart failure. Methods 76 aged patients with chronic systolic heart failure admitted to this hospital from Septmber 2011 to September 2013 were randomly divided into control group(n = 37)and MAC group(n = 39). Both groups given convention-al therapy,while the MAC group received extraly MAC. Both groups treated for 14 days. The clinical effect,heart function (LVEDV,LVESV,LVEF)and BNP level before and after treatment,and adverse reactions were recorded. Results After treatment,the total effective rate of MAC group was 94. 9% (37 / 39),was significantly higher than that of control group of 70. 2% (26 / 37)(P < 0. 05). Before treatment,there was no significant differences in LVEDV,LVESV,LVEF and BNP level between the two groups;afte treatment,LVEF was higher,BNP level was lower in MAC group than those of control group (P < 0. 05),but there was no significant differences in LVEDV,LVESV between the two groups. No one occurred severe ad-verse reactions in MAC group during treatment. Conclusion MAC has a certain clinical effect on aged patients with chronic sys-tolic heart failure,it can improve myocardial contractility and mitigate the symptoms,with good safety.