CAJ | 학술논문

根据绿色化学理念，设计水相Barbier-Grignard反应微型实验制备1-苯基-3-丁烯-1-醇，并应用于基础有机化学实验教学。采用预先活化的锌粉作试剂、大试管作反应容器、制备薄层色谱法为提纯手段，应用折射率和红外光谱对所合成产品进行了表征。结果表明，微型化实验有效地降低了实验成本、节省了实验室空间、培养了学生的环保意识，并且获得了比常量实验更高的产率和纯度，提高了实验教学效果。
근거록색화학이념，설계수상Barbier-Grignard반응미형실험제비1-분기-3-정희-1-순，병응용우기출유궤화학실험교학。채용예선활화적자분작시제、대시관작반응용기、제비박층색보법위제순수단，응용절사솔화홍외광보대소합성산품진행료표정。결과표명，미형화실험유효지강저료실험성본、절성료실험실공간、배양료학생적배보의식，병차획득료비상량실험경고적산솔화순도，제고료실험교학효과。
Miniaturized aqueous Barbier-Grignard synthesis of 1-phenyl-3-buten-1-ol is designed for students’ organic chemistry experimental teaching on the guide of green chemistry concept .The reaction is mediated by pre-activated Zinc powder ,conducted in big tube and monitored with TLC .The product is purified with TLC and characterized with refraction and IR .Results show that the miniaturization design can effectively reduce experimental cost ,save laboratory space and cultivate the students’ awareness of environmental protection .At the same time ,higher yield and purity than normal synthesis are obtained ,ensuring the effect of experimental teaching .