世界中医药
世界中醫藥
세계중의약
WORLD CHINESE MEDICINE
2014年
7期
919-922
,共4页
消风宣窍汤%过敏性鼻炎%细胞因子%行为学
消風宣纖湯%過敏性鼻炎%細胞因子%行為學
소풍선규탕%과민성비염%세포인자%행위학
Xiaofeng Xuanqiao decoction%Allergic rhinitis%Cytokine%Behavior
目的：观察消风宣窍汤对过敏性鼻炎豚鼠行为学及细胞因子的影响，以探讨其治疗机制。方法：40只Hartley豚鼠随机分为正常组、模型组、消风宣窍汤组、氯雷他定组，每组10只。采用10％二异氰酸甲苯酯（TDI）橄榄油溶液致敏豚鼠建立过敏性鼻炎动物模型，灌胃治疗1周，观察豚鼠行为学变化，用ELISA法测定血清中细胞因子IL-5、IL-12含量。结果：消风宣窍汤能明显减轻豚鼠过敏性鼻炎鼻部过敏症状以及鼻黏膜上皮炎细胞的浸润，对过敏性鼻炎豚鼠血清IL-5有显著的降低作用（P＜0.01），对IL-12有显著的升高作用（P＜0.01），两者呈负相关关系，并且效果优于开瑞坦组（P＜0.05）。结论：消风宣窍汤治疗AR的机制可能是通过降低IL-5和升高IL-12水平实现的，提示IL-5和IL-12在AR发病机制中有重要作用。
目的：觀察消風宣纖湯對過敏性鼻炎豚鼠行為學及細胞因子的影響，以探討其治療機製。方法：40隻Hartley豚鼠隨機分為正常組、模型組、消風宣纖湯組、氯雷他定組，每組10隻。採用10％二異氰痠甲苯酯（TDI）橄欖油溶液緻敏豚鼠建立過敏性鼻炎動物模型，灌胃治療1週，觀察豚鼠行為學變化，用ELISA法測定血清中細胞因子IL-5、IL-12含量。結果：消風宣纖湯能明顯減輕豚鼠過敏性鼻炎鼻部過敏癥狀以及鼻黏膜上皮炎細胞的浸潤，對過敏性鼻炎豚鼠血清IL-5有顯著的降低作用（P＜0.01），對IL-12有顯著的升高作用（P＜0.01），兩者呈負相關關繫，併且效果優于開瑞坦組（P＜0.05）。結論：消風宣纖湯治療AR的機製可能是通過降低IL-5和升高IL-12水平實現的，提示IL-5和IL-12在AR髮病機製中有重要作用。
목적：관찰소풍선규탕대과민성비염돈서행위학급세포인자적영향，이탐토기치료궤제。방법：40지Hartley돈서수궤분위정상조、모형조、소풍선규탕조、록뢰타정조，매조10지。채용10％이이청산갑분지（TDI）감람유용액치민돈서건립과민성비염동물모형，관위치료1주，관찰돈서행위학변화，용ELISA법측정혈청중세포인자IL-5、IL-12함량。결과：소풍선규탕능명현감경돈서과민성비염비부과민증상이급비점막상피염세포적침윤，대과민성비염돈서혈청IL-5유현저적강저작용（P＜0.01），대IL-12유현저적승고작용（P＜0.01），량자정부상관관계，병차효과우우개서탄조（P＜0.05）。결론：소풍선규탕치료AR적궤제가능시통과강저IL-5화승고IL-12수평실현적，제시IL-5화IL-12재AR발병궤제중유중요작용。
To study the influence of Xiaofeng Xuanqiao decoction on behavior and cytokines in allergic rhinitis models,and explore the therapeutic mechanism.Methods:Forty guinea pigs were randomized into 4 groups,normal control group,allergic rhinitis (AR)group,Xiaofeng Xuanqiao decoction group,and loratadine group.Allergic rhinitis models of guinea pigs were made by 1 0%TDI.Xiaofeng Xuanqiao decoction and loratadine were applied to inAR guinea pigs.The serum levels of IL-5 and IL-1 2 were determined by ELISA methods.Results:Xiaofeng Xuanqiao decoction could obviously relieve the hypersensitivity and infiltrate the inflammatory cells on the nasal mucosa.The serum level of IL-5 in Xiaofeng Xuanqiao decoction group significantly decreased compared with that of AR group(P<0.01 ),and the serum level of IL-1 2 in Xiaofeng Xuanqiao decoction group significantly increased (P<0.01 ).There is a positive correlation between them.The therapeutic effect of Xiaofeng Xuanqiao decoction group was better than that of loratadine group.Conclusion:The therapeutic mechanism of Xiaofeng Xuanqiao decoction on allergic rhinitis is decreasing the level of IL-5 and increasing the level of IL-1 2,which suggests that IL-5 and IL-1 2 are important factors in the pathogenesis of AR.
