世界中医药
世界中醫藥
세계중의약
WORLD CHINESE MEDICINE
2014年
7期
889-891,894
,共4页
多囊卵巢综合征%中医证型%胰岛素抵抗
多囊卵巢綜閤徵%中醫證型%胰島素牴抗
다낭란소종합정%중의증형%이도소저항
Polycysticovarysyndrome%TCMdifferentiation%Insulinresistance
目的：拟探讨多囊卵巢综合征（PCOS）患者中医证型分布规律及与糖代谢、炎性因子IGF-I、IGFBP-1的关系。方法：对120例PCOS患者进行中医证候调查，同时检测患者BMI、胰岛素抵抗稳态模式评估及胰岛素生长因子-I（IGF-I）、胰岛素生长因子结合球蛋白-1（IGFBP-1）水平。并探讨中医证型与糖代谢异常、IGF-I、IGFBP-1的关系。结果：临床辨证分为肾虚、脾虚痰湿、肝郁气滞，构成比分别为35％，33％，32％。各证型间比较P＞0.05，差异无统计学意义。脾虚痰湿组BMI、FINS、Homa-IR，P均＜0.05，差异具有统计学意义，脾虚痰湿组IGFBP-I较肾虚、肝郁气滞组下降，P均＜0.05，差异具有统计学意义，脾虚痰湿组IGF-I与肾虚、肝郁气滞组高比较升高，差异无统计学意义（P＞0.05）。结论：PCOS中医证型以肾虚、脾虚痰湿、肝郁气滞为主，脾虚痰湿证与胰岛素抵抗、IGFBP-I下降有关。
目的：擬探討多囊卵巢綜閤徵（PCOS）患者中醫證型分佈規律及與糖代謝、炎性因子IGF-I、IGFBP-1的關繫。方法：對120例PCOS患者進行中醫證候調查，同時檢測患者BMI、胰島素牴抗穩態模式評估及胰島素生長因子-I（IGF-I）、胰島素生長因子結閤毬蛋白-1（IGFBP-1）水平。併探討中醫證型與糖代謝異常、IGF-I、IGFBP-1的關繫。結果：臨床辨證分為腎虛、脾虛痰濕、肝鬱氣滯，構成比分彆為35％，33％，32％。各證型間比較P＞0.05，差異無統計學意義。脾虛痰濕組BMI、FINS、Homa-IR，P均＜0.05，差異具有統計學意義，脾虛痰濕組IGFBP-I較腎虛、肝鬱氣滯組下降，P均＜0.05，差異具有統計學意義，脾虛痰濕組IGF-I與腎虛、肝鬱氣滯組高比較升高，差異無統計學意義（P＞0.05）。結論：PCOS中醫證型以腎虛、脾虛痰濕、肝鬱氣滯為主，脾虛痰濕證與胰島素牴抗、IGFBP-I下降有關。
목적：의탐토다낭란소종합정（PCOS）환자중의증형분포규률급여당대사、염성인자IGF-I、IGFBP-1적관계。방법：대120례PCOS환자진행중의증후조사，동시검측환자BMI、이도소저항은태모식평고급이도소생장인자-I（IGF-I）、이도소생장인자결합구단백-1（IGFBP-1）수평。병탐토중의증형여당대사이상、IGF-I、IGFBP-1적관계。결과：림상변증분위신허、비허담습、간욱기체，구성비분별위35％，33％，32％。각증형간비교P＞0.05，차이무통계학의의。비허담습조BMI、FINS、Homa-IR，P균＜0.05，차이구유통계학의의，비허담습조IGFBP-I교신허、간욱기체조하강，P균＜0.05，차이구유통계학의의，비허담습조IGF-I여신허、간욱기체조고비교승고，차이무통계학의의（P＞0.05）。결론：PCOS중의증형이신허、비허담습、간욱기체위주，비허담습증여이도소저항、IGFBP-I하강유관。
To investigate the regularities of distribution of TCMdifferentiation types of polycystic ovary syndrome,and its re-lationship with glycometabolism and inflammatory factors IGF-I and IGFBP-1 .Methods:The TCM differentiation types of 1 20 cases of PCOS patients was investigated,and at the same time their BMI,homeostasis model assessment insulin resistance and insulin growth fac-tor-I(IGF-I),insulinlikegrowthfactorbindingimmunoglobulin-1(IGFBP-1) ofpatientsweremeasured.Therelationshipbetween the TCM differentiation of polycystic ovary syndrome and glycometabolism,IGF-I and IGFBP-1 were explored.Results:TCM differenti-ation types included kidney deficiency,phlegm-dampness due to deficiency of the spleen,stagnation of liver qi,and the constituent ratio was 35%,33%,and 32%.The difference in all the three groups was not significant,P>0.05.The levels of BMI,FINS,Homa-IR of phlegm-dampness due to deficiency of the spleen were higher than those of the other two groups,and the differences remained signifi-cant,P<0.05 .The level of IGFBP-I of phlegm-dampness due to deficiency of the spleen was lower than that of the other two,and the differences remained significant,P<0.05 .The level of IGF-I phlegm-dampness due to deficiency of the spleen was higher than that of the other two,and the difference was not significant,P>0.05.Conclusion:The TCMdifferentiation types of polycystic ovary syndrome mainly included kidney deficiency,phlegm-dampness due to deficiency of the spleen,stagnation of liver qi.The syndrome of phlegm-dampness due to spleen deficiency was relevant to insulin resistance and decline of IGFBP-1 .
