CAJ | 학술논문

目的：观察8%乳化异氟醚用于 Beagle 犬蛛网膜下腔后的腰麻作用以及安全性。方法18只 Beagle 犬随机分为3组,每组6只[30%脂肪乳对照组,1%利多卡因组,和(8%,v/ v)乳化异氟醚组]。实验后24h 通过核磁共振观察犬脊髓的改变,同时观察注药前后犬运动,感觉以及意识的改变。所有的犬连续观察两周,以确定有无长期神经并发症。结果所有犬的意识都没有出现减退,1%利多卡因组,8%乳化异氟醚组都出现明显的腰麻作用,MRI 未发现明显神经损伤,同时未发现感觉、运动以及行为学的改变。结论犬蛛网膜下腔注入8%的乳化异氟醚是安全有效的。
목적：관찰8%유화이불미용우 Beagle 견주망막하강후적요마작용이급안전성。방법18지 Beagle 견수궤분위3조,매조6지[30%지방유대조조,1%리다잡인조,화(8%,v/ v)유화이불미조]。실험후24h 통과핵자공진관찰견척수적개변,동시관찰주약전후견운동,감각이급의식적개변。소유적견련속관찰량주,이학정유무장기신경병발증。결과소유견적의식도몰유출현감퇴,1%리다잡인조,8%유화이불미조도출현명현적요마작용,MRI 미발현명현신경손상,동시미발현감각、운동이급행위학적개변。결론견주망막하강주입8%적유화이불미시안전유효적。
Objective To evaluate the safety and spinal anesthetic effect of the 8% emulsified isofluane in dogs. Meth-ods Eighteen adult beagle dogs completed the study. The dogs were randomly assigned into 3 groups of 6 dogs each, respectively receiving spinal administration of placebo (30% Intralipid 0. 1 mL/ kg) , 1% lidocaine(0. 1 mL/ kg) ,and (8% , v/ v)emulsified isoflurane(0. 1 mL/ kg). Sensory and motor functions and state of consciousness were determined at baseline and at predetermined regular intervals. Then the dogs were continuously observed for two weeks to examine the possible long-term neurological complica-tions. Results None of the dogs presented a decrease in consciousness. The 1% lidocaine groups and the emulsified isoflurane dosages shows a significant sensory and motor block. Conclusion Spinal administration of emulsified isoflurane resulted in a to-tally reversible motor and sensory regional block without any signs of clinical neurotoxicity.