CAJ | 학술논문

目的研究奥氮平联合丙戊酸镁缓释片治疗精神分裂症伴兴奋冲动攻击行为的临床效果。方法回顾性分析我院收治的96例精神分裂症伴兴奋冲动攻击行为患者的临床资料，根据治疗方法不同分为研究组和对照组各48例，其中对照组患者仅给予奥氮平治疗，研究组在对照组治疗基础上加用丙戊酸镁缓释片治疗，比较2组患者治疗前后PANSS评分和MOAS评分以及不良反应发生情况。结果 PANSS评分治疗前2组患者差异无统计学意义（P＞0.05），治疗后3 d治疗组低于对照组，但差异无统计学意义（P＞0.05），治疗后1周末、2周末治疗组显著低于对照组，P＜0.05；MOAS评分治疗前2组患者差异无统计学意义（P＞0.05），治疗后3 d和1周末治疗组低于对照组，差异无统计学意义（P＞0.05），治疗后2周末治疗组显著低于对照组，P＜0.05；2组患者总不良反应发生率差异无统计学意义（ P＞0.05）。结论奥氮平联合丙戊酸镁缓释片治疗精神分裂症伴兴奋冲动攻击行为患者攻击性和临床症状，效果显著，且安全性高。
목적연구오담평연합병무산미완석편치료정신분렬증반흥강충동공격행위적림상효과。방법회고성분석아원수치적96례정신분렬증반흥강충동공격행위환자적림상자료，근거치료방법불동분위연구조화대조조각48례，기중대조조환자부급여오담평치료，연구조재대조조치료기출상가용병무산미완석편치료，비교2조환자치료전후PANSS평분화MOAS평분이급불량반응발생정황。결과 PANSS평분치료전2조환자차이무통계학의의（P＞0.05），치료후3 d치료조저우대조조，단차이무통계학의의（P＞0.05），치료후1주말、2주말치료조현저저우대조조，P＜0.05；MOAS평분치료전2조환자차이무통계학의의（P＞0.05），치료후3 d화1주말치료조저우대조조，차이무통계학의의（P＞0.05），치료후2주말치료조현저저우대조조，P＜0.05；2조환자총불량반응발생솔차이무통계학의의（ P＞0.05）。결론오담평연합병무산미완석편치료정신분렬증반흥강충동공격행위환자공격성화림상증상，효과현저，차안전성고。
Objective To study the clinical effect of Olanzapine combined with magnesium valproate in the treatment of schizophrenia with excitement impulsive aggressive behavior.Methods The clinical data of 96 cases with schizophrenia excite-ment impulsive aggressive behavior in our hospital was taken for retrospective analysis. According to the different treatment methods ,they were divided into the study group and the control group ,and 48 cases in each group. The control group was on-ly given with olanzapine ,and the study group was given magnesium valproate sustained-release tablets on the basis of the con-trol group. The PANSS score and MOAS scores and adverse events of the two groups before and after treatment were com-pared.Results There was no significant difference in PANSS scores between the two groups before treatment (P>0.05). Af-ter 3 days of treatment ,PANSS scores of control group was lower than that of the control group ,but the difference was not statistically significant(P>0.05). After treatment for one week and two weeks ,the level in the treatment group was signifi-cantly lower than those of the control group(P<0.05). There was no significant difference in MOAS scores before treatment between the two groups(P>0.05). After treatment for 3 days and a week ,the level in the treatment group was lower than that of the control group ,but the difference was not statistically significant (P>0.05). After treatment for 2 weeks ,the level of the treatment group was significantly lower than that of the control group (P<0.05). There was of no significant difference in the overall incidence of adverse reactions between the two groups (P>0.05).Conclusion The effectiveness of Olanzapine combined with Magnesium valproate tablets in the treatment of schizophrenia with excitement impulsive aggressive behavior in patients with aggressive and clinical symptoms ,is significant ,and of high safety.